Current Organic Chemistry - Volume 23, Issue 13, 2019

Organodiselenides are an important class of compounds characterized by the presence of two adjacent covalently bonded selenium nuclei. Among them, diaryldiselenides and their parent compound diphenyl diselenide attract continuing interest in chemistry as well as in close disciplines like medicinal chemistry, pharmacology and biochemistry. A search in SCOPUS database has revealed that in the last three years 105 paper Read More

Matrix metalloproteinases (MMPs) are enzymes involved in various physiological processes essential for living beings, but the loss of the regulatory control by endogenous inhibitors of MMPs, leads to the development of serious diseases such as cardiovascular system affections, cancer, and metastasis. For these reasons, exogenous inhibitors are required for these enzymes, which are able to control the proteolytic activity an Read More

In this review, we try to highlight the significance, mechanism propositions, computational and experimental assessments of Hantzsch dihydropyridine (DHPs) which readily oxidized to the corresponding pyridines as one of the most important aromatic heterocycles. We also try to give an overview to its ability in transfer hydrogenation, acting as hydride donors from computational and experimental points of view. Read More

The chemistry of C5 substituted pyrimidine nucleotide serves as a versatile molecular biology probe for the incorporation of DNA/RNA that has been involved in various molecular biology applications such as gene expression, chromosome, and mRNA fluorescence in situ hybridization (FISH) experiment, mutation detection on arrays and microarrays, in situ RT-PCR, and PCR. In addition to C5 substituted pyrimidine nucleotide, Read More

Pyridoacridine alkaloids, distributed in marine organisms have emerged as an important class of compounds due to their uniqure chemical architecture, diversity and medicinal significance. These alkaloids are reported to exhibit a wide array of biological activities like anti-cancer, anti-bacterial, ant-viral, anti-fungal and anti-parasitic activities. The present review highlights the isolation, synthesis and medicinal significan Read More