Current Organic Chemistry - Volume 23, Issue 1, 2019

Hydrophobic proteins, as one of the cellular protein classifications, play an essential function in maintaining the normal life cycle of living cells. Researches on the structure and function of hydrophobic proteins promote the exploration of the causes of major diseases, and development of new therapeutic agents for disease treatment. However, the poor water solubility of hydrophobic proteins creates problems for their pr Read More

Hypervalent iodine reagents have been widely used in the construction of many important building blocks and privileged scaffolds of bioactive natural products. This review article aims to briefly discuss strategies that have used hypervalent iodine reagents as oxidants to synthesize spiroheterocyclic compounds and to stimulate further study for novel syntheses of spiroheterocyclic core structures using hypervalent io Read More

Natural cyclic peptides are conformationally constrained notable biomolecules and reveal several drug-like properties such as high binding affinity, metabolic stability, target selectivity, bioavailability, low toxicity and flexibility. They have attracted a lot of attention as alternative sources of new drugs to traditional small molecules in drug discovery. Compared to classical medicines, cyclic peptides with a novel mechanism of actio Read More

Due to special properties of ILs (ionic liquids) like their wide liquid range, good solvating ability, negligible vapour pressure, non-inflammability, environmentfriendly medium, high thermal stability, easy recycling and rate promoters etc. they are used in organic synthesis. Therefore, ionic liquids have attracted the attention of chemists and act as a catalyst and reaction medium in organic reaction with high activity. There is Read More

Tri-carbonylated oxiranes were efficiently synthesized by condensing a vicinal tricarbonyl compound with α-bromoketones in the presence of a base. This protocol was applicable to α–bromo-β-keto esters to create tetra-carbonylated oxiranes, from which trifunctionalized bromoalkene was competitively formed. The ratio of these compounds was influenced by the solvent and reaction temperature.