Current Organic Chemistry - Volume 23, Issue 22, 2019

Thio-, seleno-substituted triazoles are useful scaffolds employed in the fields of organic synthesis, medicinal chemistry, and material science. A number of synthetic approaches to efficient formation of thio- and seleno-triazoles have been disclosed, including the interception of copper(I) triazolides generated in-situ, cycloaddition of internal alkynes (thio-, halo-, and metalated alkynes) to azides, and the coupling of azides a Read More

C-N bond formation reactions are the most important transformations in (bio)organic chemistry because of the widespread occurrence of amines in pharmaceuticals, natural products, and biologically active compounds. The Hofmann rearrangement is a well-known method used for the preparation of primary amines from amides. But, the traditional version of the Hofmann rearrangement often gave relatively poor yield Read More

γ-Hydroxybutenolides (γ-HB) is an important structural core found in many bioactive marine natural products (MNPS). The γ-HB core containing NPS served as an inspiration to medicinal chemists to undertake designing of the new synthetic strategies to construct γ-HB core. Subsequently, it further results in the development of novel physiological and therapeutic agents. The most notable example includes manoalides, cacos Read More

The palladium-catalyzed reaction of aryl halide and boronic acid for the formation of C–C bonds so-called Suzuki–Miyaura cross-coupling reaction has many applications in Modern Synthetic Organic Chemistry. In 2013, we emphasized the applications of the intramolecular Suzuki cross-coupling reaction in cyclization and heterocyclization. Due to a plethora relevant papers appeared in the chemical literature, herein, we wish to c Read More

Synthesis of symmetrical 1,3-diynes from terminal alkynes through an oxidative process is generally called Glaser coupling. The classic Glaser coupling is catalyzed by copper salts under an atmosphere of molecular oxygen as an oxidant. Over the past years, different metal catalysts and oxidants were successfully used in this atom economical C-C coupling reaction. Moreover, several procedures for the preparation of uns Read More