Current Organic Chemistry - Volume 23, Issue 15, 2019

C-C cross-couplings constitute the largest diversity of organic reactions of chemical, biomedical, and industrial significance. They are also among the most frequently encountered reactions used in the synthesis of numerous drugs and relevant pharmaceutical substances. Development of an easily accessed, efficient, stable, and low cost catalyst is an attractive area of research in such kind of organic synthesis. This review hig Read More

Protein methylation is an important and reversible post-translational modification that regulates many biological processes in cells. It occurs mainly on lysine and arginine residues and involves many important biological processes, including transcriptional activity, signal transduction, and the regulation of gene expression. Protein methylation and its regulatory enzymes are related to a variety of human diseases, so improved i Read More

Lots of cold-adapted organisms could produce antifreeze proteins (AFPs) to counter the freezing of cell fluids by controlling the growth of ice crystal. AFPs have been found in various species such as in vertebrates, invertebrates, plants, bacteria, and fungi. These AFPs from fish, insects and plants displayed a high diversity. Thus, the identification of the AFPs is a challenging task in computational proteomics. With the accumul Read More

Carbazole derivatives have extensive π–conjugation due to which they are excellent organic electronics and show semiconducting properties. Carbazole-based various materials are important candidates due to their excellent redox and luminescent properties and good thermal and environmental stability, therefore, carbzole nucleus was chosen for exploring these properties. The title compound was recrystallized fro Read More

The asymmetric Friedel-Crafts reaction of indoles with imines provides a direct approach for the enantioselective construction of 3-indolyl methanamine derivatives. In this paper, a series of thiourea/ urea-tertiary amine derivatives have been used to catalyze the asymmetric F-C reaction of indoles with N-tosylimines. The effect of solvent, temperature and catalyst loading amount were investigated. the optimized Read More