Current Organic Chemistry - Volume 16, Issue 10, 2012

The journal ‘;Current Organic Chemistry’ is in its sixteenth year of publication. Over the years it has grown to be a reputable journal and has achieved an Impact Factor of 2.920. In the past years, Current Organic Chemistry has published individual reviews as well as special Hot Topic issues. This Special Anniversary issue presents the updated highly cited articles on the latest developments in various topics published in Read More

The catalytic C-C bond activation by rhodium complexes has found a wide application in organic synthesis. The course of the reaction is usually controlled by the proper ligand environment enabling processes that are otherwise not feasible under classical conditions of organic chemistry. The C-C bond activation can be achieved by the release of ringstrain in cycloalkanes (e.g. compounds possessing three- and four-membered Read More

In the past decades, chiral sulfoxides have been finding increasing use, reflecting a wide interest in both convenient auxiliaries in asymmetric synthesis and products with biological properties containing a chiral sulfinyl group. Since the breakthrough of the groups of Kagan and of Modena (1984) who discovered that modified titanium(IV) isopropoxide - diethyltartrate catalyst systems (known as “modified Katsuki-Sharpless Read More

Oxygenated steroids are bioactive compounds and valuable intermediates in the synthesis of biologically active products and APIs. This review will cover the literature from 2005/06 to the present concerning allylic oxidation, epoxidation and syn-dihydroxylation of alkenes, alcohol oxidation, and remote functionalization reactions of steroidal substrates.

The Prins reaction and the Prins cyclization have stood out as important synthetic strategies, and here the latest advances in this topic are reviewed. Different mineral acids, Lewis acids, organic acids and supported acidic materials have been employed as promoters for this type of transformation, the reaction with paraformaldehyde being the most considered one. Without any doubt, the Prins cyclization forming ox Read More

This updated version of a 2008 review presents work in the still developing field of dehydrogenative coupling reactions of phosphines. Catalytic phosphorus-element bond formation via dehydrocoupling has rapidly expanded since the first discoveries in the mid 1990s. A survey of the available catalysts, P-P and P-E products, and mechanistic understanding is presented with emphasis on the emerging synthetic applicati Read More

In the paper the introduction pointing out the important role of viologens is followed by two chapters concerning rotaxanes with a thread incorporating viologens, and those with a ring built from viologens. In the next two chapters dendrimers containing viologens as a core and those with viologens localized in their apical positions are presented. The fifth chapter deals with viologens noncovalently bound with cucurbitu Read More

Oximes are acetylcholinesterase reactivators of use in poisoning with organophosphorus inhibitors of cholinesterase (OPIChE: (organophosphates and organophosphonates). They are clinically used as an adjunct to atropine in such exposure. Clinical experience with oximes is, however, disappointing. This paper reviews available data concerning the ability of established and new oximes to reactivate cholinesterases inhib Read More