Current Organic Chemistry - Volume 16, Issue 8, 2012

The advent of host-guest catalysis brought about the prospect of a complementary mode of catalysis, with the potential for savings in cost, time and energy, easier experimental procedures, and reductions in chemical waste. Water-soluble calix[n]arene catalytic systems provide additional options in biphasic catalysis for organic chemistry and process engineering. The use of calix[n]arene as hostguest catalysis developed in Read More

Three commercially available lipases from Candida rugosa (OF and MY from Meito Sangyo Co., and CRL from Sigma- Aldrich Co.) were used for the enantioselective esterification reaction of (R,S)-ibuprofen with 1-propanol and 2-propanol in saturated cyclohexane as reaction medium. All tested lipases preferentially catalysed the esterification of the S-enantiomer of ibuprofen. However, each one of the analysed lipases demonstr Read More

(+)-Zwittermicin A is a highly polar, water-soluble aminopolyol antibiotic isolated from the soil-born bacterium B. cereus with significant activity against phytopathogenic fungi. The rising interest in zwittermicin A as a “green” biopesticide, has stimulated studies of its unique biosynthesis, mechanism of action and its organic synthesis. This review summarizes the current state of this antibiotic. A main focus of this review is Read More

The heterogeneous catalytic hydrogenation of nitriles is an important industrial process for the production of diverse amines. The reaction scheme based on the von Braun and Greenfield proposals has been widely accepted for many years and it remains the most frequently cited reaction sequence for the formation of secondary and tertiary amines via the hydrogenation of nitriles. Over the past decade, there has been a s Read More

The present work contains a comprehensive overview of methods published in the period 2005-2011 for the preparation of polyheterocycles containing isoindole-fused ring(s). New synthetic routes are described for the construction of heterocycle-condensed isoindole derivatives with regard to the ring positions and types of these annelated ring systems. On the occasion of the 60th birthday of Prof. Dr. Ferenc Fulop academician.

Several 1-aryl-hydroxy and dihydroxyisochromans were synthesized by a two-steps procedure based on the oxa-Pictet- Spengler reaction performed for the first time in dimethyl carbonate (DMC) from phenethyl alcohols and substituted benzaldehydes followed by the regioselective aromatic hydroxylation/oxidative aromatic demethylation with 2-iodoxybenzoic acid (IBX)/sodium dithionite (Na2S2O4) system. Some of Read More