Current Organic Chemistry - Volume 16, Issue 13, 2012

2-Mercaptobenzothiazole has found widespread industrial applications for the vulcanisation of rubber and, more recently, as a key component of the modified Julia olefination reaction. This review surveys the chemistry of 2-mercaptobenzothiazole, including its aromatic substitution reactions, redox chemistry and factors governing the regioselectivity of its alkylation reactions. In addition, the emerging synthetic uses of this het Read More

One-pot synthesis of symmetrical and non-symmetrical spiro[oxindole]xanthenes was achieved by reacting excess of acid labile and stable p-substituted phenols with isatin in the presence of p-TsOH in refluxing p-xylene. The intermediary 3,3-bis(2-hydroxy-5- substitutedphenyl)oxindoles undergo ring forming dehydration, generating the targeted spiro compounds. Gaining mechanistic insight allowed the selection of suitab Read More

Allenes have been shown to be versatile building blocks in organic synthesis. However, the diversity of the allene chemistry offers a challenging and exquisite task for organic chemists bent on building the suitable allene substrates. A good solution might be propargyl-allenyl isomerization, which means to prepare readily available propargyl substrates. This review focuses on recent progress in the in situ propargyl-allenyl isomeriz Read More

Organic carbamates represent an important class of compounds showing various interesting properties. They find wide utility in various areas as pharmaceuticals, agrochemicals (pesticides, herbicides, insecticides, fungicides etc.), intermediates in organic synthesis, protection of amino group in synthetic organic chemistry, as linkers in combinatorial chemistry etc. Classical synthesis of carbamates involves use of harmful reage Read More

New chiral bipyridyl alcohols and the corresponding N,N-dioxide derivatives were obtained with high enantiomeric excess by a chemo-enzymatic procedure. Metalation of commercial 6,6’-dimethyl-2,2'-bipyridine followed by reaction with acetaldehyde furnished an inseparable 1:1 mixture of dl- and meso- 6,6'-bis(2-hydroxypropyl)-2,2'-bipyridine ((±)-7a and meso-7b) that was subjected to lipasecatalysed enantioselective este Read More