Current Organic Chemistry - Volume 13, Issue 1, 2009

From a viewpoint of synthetic organic chemistry, the recent developments and applications of zirconium compounds as promoter and catalyst for many important organic reactions including addition reactions such as Michael reaction, aldo reaction, Strecker reaction and carbometalation, cycloadditions, reduction reactions, cyclization, rearrangement reactions such as Ferrier rearrangement, Fries rearrangement, the slidin Read More

In the last decades Group 6 Fischer Carbene complexes have demonstrated their ability as an interesting tool in asymmetric synthesis. The use of this family of organometallic compounds permitted the access to a wide array of optically active and occasionally enantiopure molecules. In this sense, carbo- and heterocycles of different sizes -from three to eighth membered rings- along with open chain compound, have been sy Read More

Avoiding volatile and toxic organic solvents during each particular phase of synthetic protocols should become important goal of chemical synthesis designers in academia and particularly in the industrial research community. Solvent- free reaction conditions (SFRC) are becoming a widely used experimental technique for the selective and efficient introduction of halogen atoms into organic compounds. The different approaches Read More

Last years have witnessed enormous progresses in glycomic field, mainly as a consequence of the crucial role carbohydrates have shown in biological systems. While up to a few years ago attention was mainly focused on the use of easily available D-sugars, a recent interest has emerged around their L-enantiomers, as they have been found to be key components of several bioactive compounds, whether in the form of olig Read More

L-Ascorbic acid, commonly known as vitamin C is well-known in chemistry since long back. It has tremendous medical applications in several diseases. However, application of this chiral molecule in organic synthesis has been neglected earlier. In the later part of twentieth century application of ascorbic acid has gained momentum in organic synthesis of different molecules of biological importance and of chemothe Read More