Current Organic Chemistry - Volume 13, Issue 16, 2009

With the development of catalytic asymmetric methodologies directed to the synthesis of biologically active molecules during the last years, organocatalysis has emerged as a powerful tool. The organocatalytic approach is complementary to transition metal-based catalysis within the field of asymmetric synthesis and several research groups have achieved great aims in this area by the first time. The enantioselective Fried Read More

The Mitsunobu reaction involves the “redox” condensation of an acidic pronucleophile with a primary or secondary alcohol promoted by a reactive phosphonium salt derived from an alkyl or aryl phosphine and an azo compound. The synthetic utility of the reaction is demonstrated by the wide range of acidic pronucleophiles that are tolerated including carboxylic acids, phenols, imides, hydroxamates, thiols, thioamides, fluorinat Read More

[1n]Paracyclophanes ([1n]PCPs) do not often appear in cyclophane chemistry because their synthetic strategies are limited compared to those of general o-, m-, p-[mn]cyclophanes. However, the highly symmetrical and relatively rigid structure of [1n]PCPs has attracted the interest of chemists in the fields of host-guest and molecular recognition chemistry. Some categories of [1n]PCP have been synthesized for application in pol Read More

3-Amino-4-(phenyl or p-methoxyphenyl)-6-pyridin-3-ylthieno[2,3-b]-pyridine-2-carboxamide and 3-amino-4- (phenyl or p-methoxyphenyl)-6-pyridin-3-ylthieno[2,3-b]pyridine-2-carbonitrile were used as the starting materials aiming to obtain the newly synthesized pyridothieno-pyrimidines, pyridothienotriazines and pyridothienoxazines via their reactions with several reagents e.g. CS2, HCOOH, CH(OEt)3, Ac2O and HNO2. Th Read More

Matrix-assisted laser desorption and ionization (MALDI) mass spectrometry (MS) - often but not exclusively combined with time-of-flight (TOF) mass analyzers - is one of the most successful “soft” ionization methods that is applicable to a very broad range of analytes. Although the ionization process is still widely unknown and a matter of intense research, it is commonly accepted that the matrix plays a crucial role. The devel Read More