Current Organic Chemistry - Volume 13, Issue 4, 2009

This review summarizes the synthesis of pheromones published in the triennium 2002-2004. The syntheses of a total of 66 pheromone compounds (65 from insects, 1 from a crustacean species), belonging to 9 different structural categories, are presented in schemes. New methodologies, but also well-known reactions have been employed to achieve the (in many cases stereoselective) synthesis of the compounds.

In the paper rotaxanes containing an electron accepting ring are described, they are followed by those having electron donating ring. Syntheses, properties and possible applications of considered species are presented.

The protoberberines are a widespread, important group of isoquinoline alkaloids. Due to the potent pharmacological and other bioactive properties they have achieved an increasing attention in medicinal chemistry and drug research. This article will give a brief structural classification of the protoberberines and related compounds, the biosynthesis, a compilation of new alkaloids isolated during the last decade including sourc Read More

We review recent progress in the discovery and development of small molecule inhibitors against chronic hepatitis B and C infections by listing of the current therapeutic agents and in-depth discussing chemical synthesis and biological results of the recent inhibitor candidates. At present six antiviral drugs have been formally licensed for treatment of chronic HBV infection namely interferon alfa, pegylated interferon alfa-2a a Read More

This work aimed at selective synthesis of analogues of cephalostatin 1, a highly anti-cancer marine natural product according to NCI measurements. We summarized here the work done in our laboratories of five years studying the selectivity of certain reactions of cephalostatin-like bis-steroidal pyrazines and hence, the biological activity variation. This study includes chemo-, regio- and stereoselective reactions o Read More