Current Organic Chemistry - Volume 13, Issue 14, 2009

In order to improve the biological and pharmacological properties of antisense oligonucleotides, we have been recently focused our efforts on synthesis of DNA-peptide conjugates and biological evaluation of them. Oligonucleotides can be covalently linked to peptides composed of any sequence of amino acids by Solid Phase Fragment Condensation (SPFC). The peptides incorporated into the conjugates include nuclear l Read More

The use of lipid monolayers to bind and adsorb proteins is an attractive and increasingly important method for generating high localized concentrations of oriented proteins and protein complexes. These bound proteins can be imaged directly, or they may form 2-D crystalline arrays that are amenable to structure determination by single particle analysis or 2-D electron crystallography. 2-D crystals grown by this techn Read More

The use of allene derivatives in the 1,3-dipolar cycloaddition either as dipolarophiles or 1,3-dipole precursors is discussed. Allenes participate in cycloadditions with a variety of 1,3-dipoles namely nitrile oxides, nitrones, carbonyl ylides, nitrile imines, azides and diazocompounds. They also react as the 2??-component in other annulation reactions such as the cycloaddition of ambident 1,3-dipolar species generated from ben Read More

Since the rediscovery of proline in 2000 as catalyst in aldol reaction by List, Barbas and Lerner and, soon after, the development of iminium catalysis by D. W. C. MacMillan, the emergence of organocatalysis as an important tool in organic synthesis is outstanding. During the last years, several research groups have worked in the development of new and powerful methodologies that allow us to build difficult molecules w Read More

This review deals with synthesis and reactions of 3-acetylindoles as well as their biological activities. The data published over the last few years on the methods of synthesis and chemical properties of 3-acetylindoles are reviewed here for the first time.