Current Organic Chemistry - Volume 13, Issue 10, 2009

2-Isothiocyanatobenzonitrile (ITCB) and isocyanatobenzonitrile (ICB) represent versatile difunctional building blocks containing a nitrile and an isothiocyanate or an isocyanate function, respectively. The present review provides an account of the chemistry of ITCB and ICB. This includes a number of one-pot cyclizations which provide a convenient access to a variety of pharmacologically important heterocycles.

Six new arylpiperazinylbenzofurane derivatives as potential hybrid antihypertensive agents were designed and synthesized. The discussed compounds were prepared as free bases and subsequently they were transformed into hydrochloride salts. The position of preferential protonation of nitrogen in piperazine ring in hydrochloride salts was determined by means of IR spectra, 13C CP/MAS NMR spectra and 15N CP/MAS Read More

The role of carbohydrates in tailoring the synthesis of heterocyclic compounds has grown substantially since it was last reviewed (Current Org. Chem., 2000, 4, 609). This article includes correcting, revising, inserting of missing references, and updating the earlier account. The sequence for numbering the formulae is the same as in the earlier one and the new formulae following the old ones.

Sulfamic acid has been used in many organic preparations as a good solid catalyst. In this review, we wish to report some applications of this catalyst in organic reactions.

This review highlights some of the recent progress that has been made in our laboratory and others in the field of trifluoromethylated (CF3) heterocyclic compounds starting from CF3-containing building blocks. Under mild reaction conditions, ethyl 4,4,4-trifluoroacetoacetate and its derivatives reacted with various organic reagents to produce CF3- containing N, O, S-heterocycles.