Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Nutraceuticals
  4. Volume 1, Issue 1
  5. Article
Volume 1, Issue 1
  • ISSN: 2665-9786
  • E-ISSN: 2665-9794

Abstract

Allicin from garlic is known for different medical uses for centuries. One important explanation for these effects is the chemical reactivity of allicin as a thiosulfinate towards thiol-groups and the modification of thiol-groups by thioallylation.

It has been shown that thioallylation can inhibit the enzymatic function of proteins. In different organisms, the thioallylated proteins upon allicin treatment have been examined. It was found, especially in human T-cell lymphocytes (Jurkat-cells), that the glycolysis is a major target for allicin. Here, we briefly discuss that affecting the primary metabolism is a possible part of allicin’s physiological functions and might be, both from therapeutic and nutraceutical view, of particular interest for the application of allicin as an active principle of freshly damaged garlic.

This might, in summary, explain a possible further mode of action of allicin on cells by changing the metabolism as the central life process and thus influencing the overall structure of the physiological processes in the cell, which can lead to the multitude of consequences caused by allicin.

© 2020 Martin C.H. Gruhlke
Loading

Article metrics loading...

/content/journals/cnt/10.2174/2665978601666200228092006
2020-05-01
2024-11-26

  • From This Site

    /content/journals/cnt/10.2174/2665978601666200228092006
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. BorlinghausJ. AlbrechtF. GruhlkeM.C. NwachukwuI.D. SlusarenkoA.J. Allicin: chemistry and biological properties.Molecules2014198125911261810.3390/molecules19081259125153873
     [Google Scholar]
  2. CavallitoC.J. BaileyJ.H. Allicin, the antibacterial principle of allium sativum l. isolation, physical properties and antibacterial action.J. Am. Chem. Soc.1944661950195110.1021/ja01239a048
     [Google Scholar]
  3. CavallitoC.J. BuckJ.S. SuterC.M. Allicin, the antibacterial principle of Allium sativum. II. Determination of the chemical structure.J. Am. Chem. Soc.1944661952195410.1021/ja01239a049
     [Google Scholar]
  4. GilesG.I. TaskerK.M. JacobC. Hypothesis: the role of reactive sulfur species in oxidative stress.Free Radic. Biol. Med.200131101279128310.1016/S0891‑5849(01)00710‑911705707
     [Google Scholar]
  5. GruhlkeM.C.H. SlusarenkoA.J. The biology of reactive sulfur species (RSS).Plant Physiol. Biochem.2012599810710.1016/j.plaphy.2012.03.01622541352
     [Google Scholar]
  6. BenavidesG.A. SquadritoG.L. MillsR.W. PatelH.D. IsbellT.S. PatelR.P. Darley-UsmarV.M. DoellerJ.E. KrausD.W. Hydrogen sulfide mediates the vasoactivity of garlic.Proc. Natl. Acad. Sci. USA200710446179771798210.1073/pnas.070571010417951430
     [Google Scholar]
  7. JacobC. AnwarA. The chemistry behind redox regulation with a focus on sulphur redox systems.Physiol. Plant.2008133346948010.1111/j.1399‑3054.2008.01080.x18346080
     [Google Scholar]
  8. BlockE. Garlic and Other Alliums - The Lore and the Science.1st edCambridgeRoyal Society of Chemistry2010
     [Google Scholar]
  9. MünchbergU. AnwarA. MecklenburgS. JacobC. Polysulfides as biologically active ingredients of garlic.Org. Biomol. Chem.20075101505151810.1039/B703832A17571177
     [Google Scholar]
  10. WeberN.D. AndersenD.O. NorthJ.A. MurrayB.K. LawsonL.D. HughesB.G. In vitro virucidal effects of Allium sativum (garlic) extract and compounds.Planta Med.199258541742310.1055/s‑2006‑9615041470664
     [Google Scholar]
  11. EpsteinF.H. Cardiovascular disease epidemiology: a journey from the past into the future.Circulation19969391755176410.1161/01.CIR.93.9.17558653883
     [Google Scholar]
  12. ArdittiF.D. RabinkovA. MironT. ReisnerY. BerrebiA. WilchekM. MirelmanD. Apoptotic killing of B-chronic lymphocytic leukemia tumor cells by allicin generated in situ using a rituximab-alliinase conjugate.Mol. Cancer Ther.20054232533115713903
     [Google Scholar]
  13. KelseyN.A. WilkinsH.M. LinsemanD.A. Nutraceutical antioxidants as novel neuroprotective agents.Molecules201015117792781410.3390/molecules1511779221060289
     [Google Scholar]
  14. MundayR. MundayJ.S. MundayC.M. Comparative effects of mono-, di-, tri-, and tetrasulfides derived from plants of the Allium family: redox cycling in vitro and hemolytic activity and Phase 2 enzyme induction in vivo. Free Radic. Biol. Med.20033491200121110.1016/S0891‑5849(03)00144‑812706500
     [Google Scholar]
  15. RoosG. FoloppeN. MessensJ. Understanding the pK(a) of redox cysteines: the key role of hydrogen bonding.Antioxid. Redox Signal.20131819412710.1089/ars.2012.452122746677
     [Google Scholar]
  16. WillsE.D. Enzyme inhibition by allicin, the active principle of garlic.Biochem. J.195663351452010.1042/bj063051413341914
     [Google Scholar]
  17. KubecR. HrbácováM. MusahR.A. VelísekJ. Allium discoloration: precursors involved in onion pinking and garlic greening.J. Agric. Food Chem.200452165089509410.1021/jf049745515291480
     [Google Scholar]
  18. ChoJ. LeeE.J. YooK.S. LeeS.K. PatilB.S. Identification of candidate amino acids involved in the formation of blue pigments in crushed garlic cloves (Allium sativum L.).J. Food Sci.2009741C11C1610.1111/j.1750‑3841.2008.00986.x19200080
     [Google Scholar]
  19. GuptaN. PorterT.D. Garlic and garlic-derived compounds inhibit human squalene monooxygenase.J. Nutr.200113161662166710.1093/jn/131.6.166211385050
     [Google Scholar]
  20. FockeM. FeldA. LichtenthalerK. Allicin, a naturally occurring antibiotic from garlic, specifically inhibits acetyl-CoA synthetase.FEBS Lett.1990261110610810.1016/0014‑5793(90)80647‑21968399
     [Google Scholar]
  21. FockeM. FeldA. LichtenthalerH.K. Inhibition of early steps of de novo fatty-acid biosynthesis by different xenobiotica.Physiol. Plant.199181225125510.1111/j.1399‑3054.1991.tb02138.x
     [Google Scholar]
  22. GruhlkeM.C.H. AntelmannH. BernhardtJ. KloubertV. RinkL. SlusarenkoA.J. The human allicin-proteome: S-thioallylation of proteins by the garlic defence substance allicin and its biological effects.Free Radic. Biol. Med.201913114415310.1016/j.freeradbiomed.2018.11.02230500420
     [Google Scholar]
  23. HornT. BettrayW. SlusarenkoA.J. GruhlkeM.C.H. S-allylmer-captoglutathione is a substrate for glutathione reductase (E.C. 1.8.1.7) from yeast (Saccharomyces cerevisiae). Antioxidants201877 E8610.3390/antiox707008629986384
     [Google Scholar]
  24. LeontievR. HohausN. JacobC. GruhlkeM.C.H. SlusarenkoA.J. A Comparison of the antibacterial and antifungal activities of thiosulfinate analogues of allicin.Sci. Rep.201881676310.1038/s41598‑018‑25154‑929712980
     [Google Scholar]
  25. MüllerA. EllerJ. AlbrechtF. ProchnowP. KuhlmannK. BandowJ.E. SlusarenkoA.J. LeichertL.I. HYPERLINK"http://dx.doi.org/10.1074/jbc.M115.702308" allicin induces thiol stress in bacteria through S-Allylmercapto modification of protein cysteines.J. Biol. Chem.201629122114771149010.1074/jbc.M115.702308 27008862
     [Google Scholar]
  26. LoiV.V. HuyenN.T.T. BuscheT. TungQ.N. GruhlkeM.C.H. KalinowskiJ. BernhardtJ. SlusarenkoA.J. AntelmannH. Staphylococcus aureus responds to allicin by global S-thioallylation - Role of the Brx/BSH/YpdA pathway and the disulfide reductase MerA to overcome allicin stress.Free Radic. Biol. Med.2019139556910.1016/j.freeradbiomed.2019.05.01831121222
     [Google Scholar]
  27. ReiterJ. HübbersA.M. AlbrechtF. LeichertL.I.O. SlusarenkoA.J. Allicin, a natural antimicrobial defence substance from garlic, inhibits DNA gyrase activity in bacteria.Int. J. Med. Microbiol.2019310115 1359.10.1016/j.ijmm.2019.151359 31585716
     [Google Scholar]
  28. ReiterJ. LevinaN. van der LindenM. GruhlkeM. MartinC. SlusarenkoA.J. Diallylthiosulfinate (Allicin), a volatile antimicrobial from garlic (Allium sativum), kills human lung pathogenic bacteria, including MDR strains, as a vapor.Molecules20172210171110.3390/molecules2210171129023413
     [Google Scholar]
/content/journals/cnt/10.2174/2665978601666200228092006
Loading
A (Speculative) View on Allicin and Primary Metabolism: An Additional Way to Affect Cell’s Physiology
Current Nutraceuticals 1, 14; https://doi.org/10.2174/2665978601666200228092006
/content/journals/cnt/10.2174/2665978601666200228092006
/content/journals/cnt/10.2174/2665978601666200228092006
Loading

Data & Media loading...


  • Article Type:     Other
Keyword(s): Allicin; garlic; glycolysis; primary metabolism; protein modification; thioallylation

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test