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Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Objective

The objective of this study is to investigate whether quantitatively measured infrapatellar fat pad (IPFP) signal intensity alteration is associated with joint effusion-synovitis in people with knee osteoarthritis (OA) over two years.

Methods

Among 255 knee OA patients, IPFP signal intensity alteration represented by four measurement parameters [standard deviation of IPFP signal intensity (IPFP sDev), upper quartile value of IPFP high signal intensity region (IPFP UQ (H)), ratio of IPFP high signal intensity region volume to whole IPFP volume (IPFP percentage (H)), and clustering factor of IPFP high signal intensity (IPFP clustering factor (H))] was measured quantitatively at baseline and two-year follow-up using magnetic resonance imaging (MRI). Effusion-synovitis of the suprapatellar pouch and other cavities were measured both quantitatively and semi-quantitatively as effusion-synovitis volume and effusion-synovitis score at baseline and two-year follow-up using MRI. Mixed effects models assessed the associations between IPFP signal intensity alteration and effusion-synovitis over two years.

Results

In multivariable analyses, all four parameters of IPFP signal intensity alteration were positively associated with total effusion-synovitis volume and effusion-synovitis volumes of the suprapatellar pouch and of other cavities over two years (all <0.05). They were also associated with the semi-quantitative measure of effusion-synovitis except for IPFP percentage (H) with effusion-synovitis in other cavities.

Conclusion

Quantitatively measured IPFP signal intensity alteration is positively associated with joint effusion-synovitis in people with knee OA, suggesting that IPFP signal intensity alteration may contribute to effusion-synovitis and a coexistent pattern of these two imaging biomarkers could exist in knee OA patients.

© 2023 Ruan et al.
© 2024 The Author(s). Published by Bentham Science Publisher. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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2024-01-01
2024-11-26

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References

  1. RuanG. XuJ. WangK. ZhengS. WuJ. RenJ. BianF. ChangB. ZhuZ. HanW. DingC. Associations between serum S100A8/S100A9 and knee symptoms, joint structures and cartilage enzymes in patients with knee osteoarthritis.Osteoarthritis Cartilage20192719910510.1016/j.joca.2018.08.02030240939
     [Google Scholar]
  2. WangK. DingC. HannonM.J. ChenZ. KwohC.K. HunterD.J. Quantitative signal intensity alteration in infrapatellar fat pad predicts incident radiographic osteoarthritis: The osteoarthritis initiative.Arthritis Care Res.2019711303810.1002/acr.2357729648688
     [Google Scholar]
  3. MathiessenA. ConaghanP.G. Synovitis in osteoarthritis: Current understanding with therapeutic implications.Arthritis Res. Ther.20171911810.1186/s13075‑017‑1229‑928148295
     [Google Scholar]
  4. HügleT. GeurtsJ. What drives osteoarthritis?-synovial versus subchondral bone pathology.Rheumatology20175691461147128003493
     [Google Scholar]
  5. BurkeC.J. AlizaiH. BeltranL.S. RegatteR.R. MRI of synovitis and joint fluid.J. Magn. Reson. Imaging20194961512152710.1002/jmri.2661830618151
     [Google Scholar]
  6. WangX. JinX. BlizzardL. AntonyB. HanW. ZhuZ. CicuttiniF. WlukaA.E. WinzenbergT. JonesG. DingC. Associations between knee effusion-synovitis and joint structural changes in patients with knee osteoarthritis.J. Rheumatol.201744111644165110.3899/jrheum.16159628864651
     [Google Scholar]
  7. MacFarlaneL.A. YangH. CollinsJ.E. JarrayaM. GuermaziA. MandlL.A. MartinS.D. WrightJ. LosinaE. KatzJ.N. BrophyR.H. LevyB.A. MarxR.G. MatavaM. Safran-NortonC. SpindlerK.P. StuartM. DahmD.L. WrightR. Association of changes in effusion-synovitis with progression of cartilage damage over eighteen months in patients with osteoarthritis and meniscal tear.Arthritis Rheumatol.2019711738110.1002/art.4066030133187
     [Google Scholar]
  8. HarkeyM.S. DavisJ.E. LuB. PriceL.L. WardR.J. MacKayJ.W. EatonC.B. LoG.H. BarbeM.F. ZhangM. PangJ. StoutA.C. McAlindonT.E. DribanJ.B. Early pre-radiographic structural pathology precedes the onset of accelerated knee osteoarthritis.BMC Musculoskelet. Disord.201920124110.1186/s12891‑019‑2624‑y31113401
     [Google Scholar]
  9. DavisJ.E. WardR.J. MacKayJ.W. LuB. PriceL.L. McAlindonT.E. EatonC.B. BarbeM.F. LoG.H. HarkeyM.S. DribanJ.B. Effusion-synovitis and infrapatellar fat pad signal intensity alteration differentiate accelerated knee osteoarthritis.Rheumatology201958341842610.1093/rheumatology/key30530346594
     [Google Scholar]
  10. JiangL.F. FangJ.H. WuL.D. Role of infrapatellar fat pad in pathological process of knee osteoarthritis: Future applications in treatment.World J. Clin. Cases20197162134214210.12998/wjcc.v7.i16.213431531309
     [Google Scholar]
  11. HanW. AitkenD. ZhengS. WlukaA.E. ZhuZ. BlizzardL. WinzenbergT. CicuttiniF. JonesG. DingC. Association between quantitatively measured infrapatellar fat pad high signal-intensity alteration and magnetic resonance imaging–assessed progression of knee osteoarthritis.Arthritis Care Res.201971563864610.1002/acr.2371330044537
     [Google Scholar]
  12. ChangJ. LiaoZ. LuM. MengT. HanW. DingC. Systemic and local adipose tissue in knee osteoarthritis.Osteoarthritis Cartilage201826786487110.1016/j.joca.2018.03.00429578044
     [Google Scholar]
  13. WangK. DingC. HannonM.J. ChenZ. KwohC.K. LynchJ. HunterD.J. Signal intensity alteration within infrapatellar fat pad predicts knee replacement within 5 years: data from the Osteoarthritis Initiative.Osteoarthritis Cartilage201826101345135010.1016/j.joca.2018.05.01529842941
     [Google Scholar]
  14. LuM. ChenZ. HanW. ZhuZ. JinX. HunterD.J. DingC. A novel method for assessing signal intensity within infrapatellar fat pad on MR images in patients with knee osteoarthritis.Osteoarthritis Cartilage201624111883188910.1016/j.joca.2016.06.00827327783
     [Google Scholar]
  15. MacchiV. StoccoE. SteccoC. BelluzziE. FaveroM. PorzionatoA. De CaroR. The infrapatellar fat pad and the synovial membrane: an anatomo-functional unit.J. Anat.2018233214615410.1111/joa.1282029761471
     [Google Scholar]
  16. JinX. JonesG. CicuttiniF. WlukaA. ZhuZ. HanW. AntonyB. WangX. WinzenbergT. BlizzardL. DingC. Effect of vitamin D supplementation on tibial cartilage volume and knee pain among patients with symptomatic knee osteoarthritis.JAMA2016315101005101310.1001/jama.2016.196126954409
     [Google Scholar]
  17. AltmanR. AschE. BlochD. BoleG. BorensteinD. BrandtK. ChristyW. CookeT.D. GreenwaldR. HochbergM. HowellD. KaplanD. KoopmanW. LongleyS. MankinH. McShaneD.J. MedsgerT. MeenanR. MikkelsenW. MoskowitzR. MurphyW. RothschildB. SegalM. SokoloffL. WolfeF. Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee.Arthritis Rheum.19862981039104910.1002/art.17802908163741515
     [Google Scholar]
  18. HochbergM.C. ChangR.W. DwoshI. LindseyS. PincusT. WolfeF. The american college of rheumatology 1991 revised criteria for the classification of global functional status in rheumatoid arthritis.Arthritis Rheum.199235549850210.1002/art.17803505021575785
     [Google Scholar]
  19. AltmanR.D. GoldG.E. Atlas of individual radiographic features in osteoarthritis, revised.Osteoarthritis Cartilage200715Suppl AA15610.1016/j.joca.2006.11.009
     [Google Scholar]
  20. LaffontC.M. VandemeulebroeckeM. ConcordetD. Multivariate analysis of longitudinal ordinal data with mixed effects models, with application to clinical outcomes in osteoarthritis.J. Am. Stat. Assoc.201410950795596610.1080/01621459.2014.917977
     [Google Scholar]
  21. HanW. AitkenD. ZhuZ. HallidayA. WangX. AntonyB. CicuttiniF. JonesG. DingC. Signal intensity alteration in the infrapatellar fat pad at baseline for the prediction of knee symptoms and structure in older adults: A cohort study.Ann. Rheum. Dis.201675101783178810.1136/annrheumdis‑2015‑20836026612337
     [Google Scholar]
  22. HanW. AitkenD. ZhuZ. HallidayA. WangX. AntonyB. CicuttiniF. JonesG. DingC. Hypointense signals in the infrapatellar fat pad assessed by magnetic resonance imaging are associated with knee symptoms and structure in older adults: a cohort study.Arthritis Res. Ther.201618123410.1186/s13075‑016‑1130‑y27729069
     [Google Scholar]
  23. BallegaardC. RiisR.G.C. BliddalH. ChristensenR. HenriksenM. BartelsE.M. LohmanderL.S. HunterD.J. BouertR. BoesenM. Knee pain and inflammation in the infrapatellar fat pad estimated by conventional and dynamic contrast-enhanced magnetic resonance imaging in obese patients with osteoarthritis: A cross-sectional study.Osteoarthritis Cartilage201422793394010.1016/j.joca.2014.04.01824821663
     [Google Scholar]
  24. RoemerF.W. KwohC.K. HannonM.J. HunterD.J. EcksteinF. FujiiT. BoudreauR.M. GuermaziA. What comes first? multitissue involvement leading to radiographic osteoarthritis: Magnetic resonance imaging-based trajectory analysis over four years in the osteoarthritis initiative.Arthritis Rheumatol.20156782085209610.1002/art.3917625940308
     [Google Scholar]
  25. YunS.J. LimY. JinW. ParkY.S. LeeS.H. RyuK.N. Validity of radiograph-based infrapatellar fat pad opacity grading for assessing knee synovitis: Correlation with contrast-enhanced MRI.AJR Am. J. Roentgenol.201720961321133010.2214/AJR.16.1771829045182
     [Google Scholar]
  26. HeilmeierU. MamotoK. AmanoK. EckB. TanakaM. BullenJ.A. SchwaigerB.J. HuebnerJ.L. StablerT.V. KrausV.B. MaC.B. LinkT.M. LiX. Infrapatellar fat pad abnormalities are associated with a higher inflammatory synovial fluid cytokine profile in young adults following ACL tear.Osteoarthritis Cartilage2020281829110.1016/j.joca.2019.09.00131526878
     [Google Scholar]
  27. EymardF. PigenetA. CitadelleD. Flouzat-LachanietteC.H. PoignardA. BenelliC. BerenbaumF. ChevalierX. HouardX. Induction of an inflammatory and prodegradative phenotype in autologous fibroblast-like synoviocytes by the infrapatellar fat pad from patients with knee osteoarthritis.Arthritis Rheumatol.20146682165217410.1002/art.3865724719336
     [Google Scholar]
/content/journals/cmir/10.2174/1573405619666230310093402
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Quantitatively Measured Infrapatellar Fat Pad Signal Intensity Alteration is Associated with Joint Effusion-synovitis in Knee Osteoarthritis
Curr. Med. Imaging 20, E100323214543 (2024); https://doi.org/10.2174/1573405619666230310093402
/content/journals/cmir/10.2174/1573405619666230310093402
/content/journals/cmir/10.2174/1573405619666230310093402
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  • Article Type:     Research Article
Keyword(s): Cartilage; Effusion-synovitis; Infrapatellar fat pad; MRI; Osteoarthritis; Osteophyte

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