Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Medical Imaging
  4. Volume 20, Issue 1
  5. Article
Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
file format pdf download PDF
side by side viewer icon HTML

Abstract

Background

Castleman disease (CD) is a rare lymphoproliferative disorder, with intracranial involvement being exceedingly rare. Unicentric Castleman disease (UCD) is typically benign and localized, but its presentation can mimic other intracranial pathologies, complicating diagnosis.

Case Description

We reported a 52-year-old woman who presented with progressive headaches and language disturbances. Imaging, including MRI and CT, revealed an extra-axial left frontotemporal lesion initially diagnosed as an en plaque meningioma. Surgical resection of the lesion was performed. Histopathological examination revealed UCD with plasma cell predominance, characterized by lymphoid hyperplasia and concentric germinal centers. Immunohistochemical staining confirmed the diagnosis, with positive markers including CD20, CD3, and CD16.

Conclusion

Intracranial UCD is a rare and challenging differential diagnosis for extra-axial lesions, often resembling meningiomas. Accurate diagnosis requires a combination of imaging and histopathology, with immunohistochemistry playing a crucial role. Complete surgical resection is the optimal treatment for localized UCD.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Loading

Article metrics loading...

/content/journals/cmir/10.2174/0115734056343564241120113055
2024-01-01
2025-04-25

  • From This Site

    /content/journals/cmir/10.2174/0115734056343564241120113055
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
The full text of this item is not currently available.

References

  1. González GarcíaA. Fernández-MartínJ. Robles MarhuendaÁ. Idiopathic multicentric Castleman disease and associated autoimmune and autoinflammatory conditions: Practical guidance for diagnosis.Rheumatology (Oxford)20236241426143510.1093/rheumatology/keac48135997567
     [Google Scholar]
  2. MatsumuraK. NakasuS. TanakaT. NiokaH. MatsudaM. Intracranial localized Castleman’s disease. Case report.Neurol. Med. Chir. (Tokyo)2005451596510.2176/nmc.45.5915699624
     [Google Scholar]
  3. PawarR.V. FatterpekarG.M. ZagzagD. ParkerE.C. NarayanaA. Multicentric Castleman’s disease of the central nervous system : Evaluation with dynamic susceptibility contrast perfusion magnetic resonance imaging.Clin. Neuroradiol.201222324525110.1007/s00062‑011‑0090‑521837500
     [Google Scholar]
  4. WongR.S.M. Unicentric Castleman disease.Hematol. Oncol. Clin. North Am.2018321657310.1016/j.hoc.2017.09.00629157620
     [Google Scholar]
  5. WuD. LimM.S. JaffeE.S. Pathology of Castleman disease.Hematol. Oncol. Clin. North Am.2018321375210.1016/j.hoc.2017.09.00429157618
     [Google Scholar]
  6. WangY. ZhouL. WangW. ChengH. Intracranial Castleman disease presenting as a meningioma.World Neurosurg.202014242042210.1016/j.wneu.2020.07.04332679358
     [Google Scholar]
  7. HashimotoH. IidaJ. HironakaY. SakakiT. Intracranial Castleman’s disease of solitary form.J. Neurosurg.199990356356610.3171/jns.1999.90.3.056310067931
     [Google Scholar]
  8. RibeiroL.T. SimãoG.N. MatosA.L.M. CarlottiC.G.Jr ColliB.O. NederL. Ribeiro-SilvaA. de CastroM. RegoE. SantosA.C. Intracranial Castleman’s disease presenting as hypopituitarism.Neuroradiology2004461083083310.1007/s00234‑004‑1253‑815300344
     [Google Scholar]
  9. ShuaipajT. AbutalibS.A. ChenY.H. GaitondeS. LindgrenV. Intracranial plasmacytoma mimicking meningioma in a patient with Castleman’s disease.Am. J. Hematol.200984319519610.1002/ajh.2134519202549
     [Google Scholar]
  10. MallikA.A. KatchyK.C. ClotanN. Solitary intracranial Castleman’s disease, plasma cell variant: A case report.Med. Princ. Pract.200716322622910.1159/00010039517409759
     [Google Scholar]
  11. ZhaoD. OzdemirliM. NayarV. Intracranial Castleman disease: Illustrative case and literature review.Interdiscip. Neurosurg.20222710141810.1016/j.inat.2021.101418
     [Google Scholar]
  12. Escribano ParedesJ.B. Carrasco MoroR. López GutiérrezM. AriasH.P. García-CosíoM. García MadronaS. Nedkova HristovaV. Martínez PolesJ. FranciscoJ.B.C. Radiologic and histopathologic features in an intracranial localized castleman disease.Neurologist2019241333610.1097/NRL.000000000000020330586033
     [Google Scholar]
  13. DelmontE. LonjonM. MichielsJ.F. ChanaletS. BourgV. XerriL. BondiauP.Y. LebrunC. [Castleman’s disease located in the central nervous system].Rev. Neurol. (Paris)20031595 Pt 158158512773906
     [Google Scholar]
  14. GündüzE. ÖzdemirN. BakanayS.M. KarakuşS. A rare Lymphoproliferative disease: Castleman disease.Turk. J. Haematol.202138431432034719151
     [Google Scholar]
  15. CarboneA. BorokM. DamaniaB. GloghiniA. PolizzottoM.N. JayanthanR.K. FajgenbaumD.C. BowerM. Castleman disease.Nat. Rev. Dis. Primers2021718410.1038/s41572‑021‑00317‑734824298
     [Google Scholar]
  16. CocaS. SalasI. MartínezR. SaezM.A. VaqueroJ. Meningeal Castleman’s disease with multifocal involvement: A case report and review of literature.J. Neurooncol.2008881374110.1007/s11060‑008‑9528‑218204819
     [Google Scholar]
  17. SotrelA. Castellano-SanchezA.A. PrusmackC. BirchanskyS. BrathwaiteC. RaghebJ. Castleman’s disease in a child presenting with a partly mineralized solitary meningeal mass.Pediatr. Neurosurg.200338523223710.1159/00006982112686765
     [Google Scholar]
  18. YoshidaK. SuzukiT. SakataT. KawaiN. MatsudaA. KayanoH. HirashimaK. MatsutaniM. BesshoM. Successful treatment of multicentric Castleman’s disease with intracranial and retroperitoneal tumors.Intern. Med.200140997697710.2169/internalmedicine.40.97611579970
     [Google Scholar]
/content/journals/cmir/10.2174/0115734056343564241120113055
Loading
Intracranial Castleman’s Disease Mimicking Dural-based Pathologies: A Case Report
Curr. Med. Imaging 20, e15734056343564 (2024); https://doi.org/10.2174/0115734056343564241120113055
/content/journals/cmir/10.2174/0115734056343564241120113055
/content/journals/cmir/10.2174/0115734056343564241120113055
Loading

Data & Media loading...


  • Article Type:     Case Report
Keyword(s): Hyaline vascular type; Intracranial castleman disease; Lymphoproliferative disease; Plaque meningioma; Plasma cell type; Unicentric Castleman Disease

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test