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Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Background

Columnar cell carcinoma is a rare subtype of papillary thyroid carcinoma (CCV-PTC) that accounts for only 0.15% to 0.2% of all Papillary Thyroid Carcinomas (PTCs). It has aggressive behavior but a better prognosis than anaplastic thyroid carcinoma.

Case Presentation

A 64-year-old female presented with a huge thyroid mass resulting in compressive myelopathy and was diagnosed as CCV-PTC, not anaplastic carcinoma. After multidisciplinary discussions, we decided to proceed with otolaryngological, thoracic, and orthopaedic surgery. All tumours were unresectable, and we planned to proceed with R2 resection to resolve the gait disturbance and anterior fusion to resolve spinal instability.

Conclusion

Advanced-stage thyroid cancer is relatively uncommon, but desirable treatment effects can be expected through accurate pathological diagnosis. Immunohistochemical staining and tissue-specific markers can be helpful.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2024-04-30
2025-01-04

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References

  1. BenvengaS. Thyroid gland: anatomy and physiology.Encyclopedia of Endocrine Diseases20184382390
     [Google Scholar]
  2. SywakM. PasiekaJ.L. OgilvieT. A review of thyroid cancer with intermediate differentiation.J. Surg. Oncol.2004861445410.1002/jso.2004415048680
     [Google Scholar]
  3. LeeJ.H. ShinJ.H. LeeH.W. OhY.L. HahnS.Y. KoE.Y. Sonographic and cytopathologic correlation of papillary thyroid carcinoma variants.J. Ultrasound Med.201534111510.7863/ultra.34.1.125542934
     [Google Scholar]
  4. Cameselle-TeijeiroJ.M. EloyC. Sobrinho-SimõesM. Pitfalls in challenging thyroid tumors: emphasis on differential diagnosis and ancillary biomarkers.Endocr. Pathol.202031319721710.1007/s12022‑020‑09638‑x32632840
     [Google Scholar]
  5. HaugenB.R. AlexanderE.K. BibleK.C. DohertyG.M. MandelS.J. NikiforovY.E. PaciniF. RandolphG.W. SawkaA.M. SchlumbergerM. SchuffK.G. ShermanS.I. SosaJ.A. StewardD.L. TuttleR.M. WartofskyL. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer.Thyroid2016261113310.1089/thy.2015.002026462967
     [Google Scholar]
  6. ChenJ.H. FaquinW.C. LloydR.V. NoséV. Clinicopathological and molecular characterization of nine cases of columnar cell variant of papillary thyroid carcinoma.Mod. Pathol.201124573974910.1038/modpathol.2011.221358618
     [Google Scholar]
  7. ChoJ. ShinJ.H. HahnS.Y. OhY.L. Columnar cell variant of papillary thyroid carcinoma: ultrasonographic and clinical differentiation between the indolent and aggressive types.Korean J. Radiol.20181951000100510.3348/kjr.2018.19.5.100030174490
     [Google Scholar]
  8. HundahlS.A. FlemingI.D. FremgenA.M. MenckH.R. A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985-1995.Cancer199883122638264810.1002/(SICI)1097‑0142(19981215)83:12<2638::AID‑CNCR31>3.0.CO;2‑19874472
     [Google Scholar]
  9. HoA.S. LuuM. BarriosL. ChenI. MelanyM. AliN. PatioC. ChenY. BoseS. FanX. Mallen-St ClairJ. BraunsteinG.D. SacksW.L. ZumstegZ.S. Incidence and mortality risk spectrum across aggressive variants of papillary thyroid carcinoma.JAMA Oncol.20206570671310.1001/jamaoncol.2019.685132134428
     [Google Scholar]
  10. WangS. XiongY. ZhaoQ. SongH. YiP. LiuC. Columnar cell papillary thyroid carcinoma prognosis: findings from the SEER database using propensity score matching analysis.Am. J. Transl. Res.20191196262627031632592
     [Google Scholar]
  11. CrescenziA. BalochZ. Immunohistochemistry in the pathologic diagnosis and management of thyroid neoplasms.Front. Endocrinol. (Lausanne)202314119809910.3389/fendo.2023.119809937324272
     [Google Scholar]
  12. EnriquezM.L. BalochZ.W. MontoneK.T. ZhangP.J. LiVolsiV.A. CDX2 expression in columnar cell variant of papillary thyroid carcinoma.Am. J. Clin. Pathol.2012137572272610.1309/AJCPXE3PUBWVZCGZ22523209
     [Google Scholar]
  13. BaiY. KakudoK. JungC.K. Updates in the pathologic classification of thyroid neoplasms: a review of the World Health Organization classification.Endocrinol. Metab. (Seoul)202035469671510.3803/EnM.2020.80733261309
     [Google Scholar]
  14. LiY. Total versus subtotal thyroidectomy for differentiated thyroid carcinoma and their influence on related indexes.Int. J. Clin. Exp. Med.2020131080078013
     [Google Scholar]
  15. RagazziM. Update on anaplastic thyroid carcinoma: morphological, molecular, and genetic features of the most aggressive thyroid cancer.Int. J. Endocrinol.2014201410.1155/2014/790834
     [Google Scholar]
  16. XuB. FuchsT. DoganS. LandaI. KatabiN. FaginJ.A. TuttleR.M. ShermanE. GillA.J. GhosseinR. Dissecting anaplastic thyroid carcinoma: a comprehensive clinical, histologic, immunophenotypic, and molecular study of 360 cases.Thyroid202030101505151710.1089/thy.2020.008632284020
     [Google Scholar]
  17. GjeluciA. ClarkJ. JawaharA. Rare columnar cell variant papillary thyroid carcinoma with metastasis to pancreas and lungs at initial presentation: A case report and review of literature.J Gastroint Abdom Radiol2022601062066
     [Google Scholar]
  18. MulitaF. TheofanisG. VerrasG.I. LiolisE. PapanikosV. TchabashviliL. TasiosK. IliopoulosF. TsilivigkosC. KehagiasD. KaplanisC. AntzoulasA. SamarasA. DrakosN. PanagiotopoulosI. LeivaditisV. FilisD. MaroulisI. BouchagierK. MichalakiM. Comparison of postoperative bleeding using harmonic scalpel and LigaSure in thyroid surgery: a 15-year single-centre retrospective study.Med. Glas.202320237585298
     [Google Scholar]
/content/journals/cmir/10.2174/0115734056300884240402050738
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Rare Columnar Cell Variant of Papillary Thyroid Carcinoma with Cervical Spine Metastasis: A Case Report
Curr. Med. Imaging 20, e15734056300884 (2024); https://doi.org/10.2174/0115734056300884240402050738
/content/journals/cmir/10.2174/0115734056300884240402050738
/content/journals/cmir/10.2174/0115734056300884240402050738
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  • Article Type:     Case Report
Keyword(s): CDX2 expression; Columnar cell carcinoma; Neck; Thyroid gland; Tumour; Variant of papillary thyroid carcinoma

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