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Volume 1, Issue 1
  • ISSN: 2210-299X
  • E-ISSN: 2210-3007
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Abstract

Background

Developmental toxicology deals with the effects of compounds on fertility and with birth defects that could occur at any stage of the reproductive cycle. In this study, we evaluated the teratogenic effects of (L.) Sweet beans on zebrafish embryo.

Objectives

The developmental toxicity study was carried out to evaluate the toxicity induced by (L.) Sweet beans on zebrafish embryo. We also studied the cytotoxicity of (L.) Sweet beans.

Methods

Zebrafish embryos were exposed to a methanolic extract of (L.) Sweet beans at concentrations of 10,25,50, and 100 μg/ml starting from 24 hours post fertilization (HPF) to 72 HPF. Developmental defects, if any, were observed under a microscope. Cytotoxicity of (L.) Sweet beans were also evaluated by using brine shrimp and the corresponding LC value of the methanolic extract of (L.) Sweet beans were also calculated.

Results

The LC50 value of the methanolic extract of (L.) Sweet beans were found to be 77 μg/ml. However, some forms of developmental toxicity were observed in zebrafish embryos when treated with different concentrations of (L.) Sweet beans extract.

Conclusion

The methanolic extract of (L.) Sweet beans were found to be cytotoxic in brine shrimp, and the LC value was found to be 77 μg/ml. However, there was some level of developmental toxicity in the Zebrafish embryo model at different concentrations of (L.) Sweet beans extract.

© 2023 Bentham Science Publishers
© 2023 The Author(s). Published by Bentham Science Publisher. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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/content/journals/cis/10.2174/2210299X01666230515090815
2023-01-01
2024-11-22

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/content/journals/cis/10.2174/2210299X01666230515090815
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Investigation of Developmental Toxicity Profile of Edible Lablab (Lablab purpureus (l.) Sweet Purpurea) bean Extract using Brine Shrimp and Zebrafish
Curr. Indian Sci. 1, e150523216896 (2023); https://doi.org/10.2174/2210299X01666230515090815
/content/journals/cis/10.2174/2210299X01666230515090815
/content/journals/cis/10.2174/2210299X01666230515090815
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  • Article Type:     Research Article
Keyword(s): Brine shrimp; Developmental toxicology; Lablab purpureus(L.) Sweet purpurea; Sweet beans; Toxicity; Zebrafish embryo

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