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2000
Volume 1, Issue 1
  • ISSN: 2210-299X
  • E-ISSN: 2210-3007

Abstract

Plants are admired for their taste, fragrance, and therapeutic characteristics. Herbs are used in multiple traditions, including cooking, medicine, and spirituality. Medicinal plants have been used to treat a number of illnesses and disorders from ancient times to the present day. The main reason for this is that therapeutic plants have no negative side effects. With a diverse spectrum of plant species and widespread access to traditional medical practices, India is one of the world's largest biodiversity reservoirs. According to WHO data and other relevant sources, herbal medicinal products are used by more than 80% of the world's population. The goal of this review article is to describe the importance of herbal agents in therapeutics, such as the use of crude plant extract for the medicinal purpose. Complex interaction of blood cells, tissues, soluble mediators, cytokines, and numerous growth factors is required for wound healing, whether it is accidental or surgical. Plants have enormous potential for wound management and therapy, as well as regeneration of damaged tissues, due to the presence of a variety of useful active phytoconstituents. This review presents comprehensive data on some important plants and their extracts used in wound healing along with their mechanism of action and the scientific research reported on these plants.

© 2023 The Author(s). Published by Bentham Science Publisher. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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References

  1. ChahK.F. EzeC.A. EmuelosiC.E. EsimoneC.O. Antibacterial and wound healing properties of methanolic extracts of some Nigerian medicinal plants.J. Ethnopharmacol.20061041-216416710.1016/j.jep.2005.08.07016226414
    [Google Scholar]
  2. FabricantD.S. FarnsworthN.R. The value of plants used in traditional medicine for drug discovery.Environ. Health Perspect.2001109Suppl. 1697510.1289/ehp.01109s16911250806
    [Google Scholar]
  3. PrincipeP.P. Monetizing the pharmacological benefits of plants. Medicinal Resources of the Tropical Forest: Biodiversity and Its Importance to Human Health. BalickM.J. ElisabetskyE. LairdS.A. Columbia University Press1996191219
    [Google Scholar]
  4. JiangX. Effect of Bauhinia championii (Benth.) Benth extract on Streptococcus mutants in vitro.Biomed. Res.2016273758761
    [Google Scholar]
  5. Gurib-FakimA. Medicinal plants: Traditions of yesterday and drugs of tomorrow.Mol. Aspects Med.200627119310.1016/j.mam.2005.07.00816105678
    [Google Scholar]
  6. Senthil KumarM. SripriyaR. Vijaya RaghavanH. SehgalP.K. Wound healing potential of Cassia fistula on infected albino rat model.J. Surg. Res.2006131228328910.1016/j.jss.2005.08.02516242721
    [Google Scholar]
  7. SinghM. GovindarajanR. NathV. RawatA.K.S. MehrotraS. Antimicrobial, wound healing and antioxidant activity of Plagiochasma appendiculatum Lehm. et Lind.J. Ethnopharmacol.20061071677210.1016/j.jep.2006.02.00716600543
    [Google Scholar]
  8. EnochS. LeaperD.J. Basic science of wound healing.Surgery2008262313710.1016/j.mpsur.2007.11.005
    [Google Scholar]
  9. SumitraM. ManikandanP. SugunaL. Efficacy of Butea monosperma on dermal wound healing in rats.Int. J. Biochem. Cell Biol.200537356657310.1016/j.biocel.2004.08.00315618014
    [Google Scholar]
  10. KrishnanP. The scientific study of herbal wound healing therapies: Current state of play.Curr. Anaesth. Crit. Care2006171-2212710.1016/j.cacc.2006.02.009
    [Google Scholar]
  11. NejatiR. KovacicD. SlominskiA. Neuro-ImmuneEndocrine Functions ofTe Skin: An Overview.Taylor & Francis2013
    [Google Scholar]
  12. PasparakisM. HaaseI. NestleF.O. Mechanisms regulating skin immunity and inflammation.Nat. Rev. Immunol.201414528930110.1038/nri364624722477
    [Google Scholar]
  13. RousselleP. BrayeF. DayanG. Re-epithelialization of adult skin wounds: Cellular mechanisms and therapeutic strategies.Adv. Drug Deliv. Rev.201914634436529981800
    [Google Scholar]
  14. KupperT.S. FuhlbriggeR.C. Immune surveillance in the skin: mechanisms and clinical consequences.Nat. Rev. Immunol.20044321122210.1038/nri131015039758
    [Google Scholar]
  15. Emami-RazaviH Effect of bentonite on skin wound healing experimental study in the rat model.Acta Med. Iran.2006444235240
    [Google Scholar]
  16. ClarkR.A.F. Cutaneous tissue repair: Basic biologic considerations. I.J. Am. Acad. Dermatol.198513570172510.1016/S0190‑9622(85)70213‑72416789
    [Google Scholar]
  17. ArunachalamKantha Preliminary phytochemical Investigation and wound healing activity of Myristica andamanica leaves in Swiss albino mice.J. Med. Plants Res.20115710951106
    [Google Scholar]
  18. DanM.M. SarmahP. VanaD.R. DattatreyaA. Wound Healing: Concepts and updates in herbal medicine.Int. J. Med. Res. Health Sci.201871170181
    [Google Scholar]
  19. MarumeA. MatopeG. KatsandeS. KhozaS. MutingwendeI. MduluzaT. Munodawafa-TadereraT. NdhlalaA.R. Wound healing properties of selected plants used in ethnoveterinary medicine.Front. Pharmacol.2017854410.3389/fphar.2017.0054428932192
    [Google Scholar]
  20. FlanaganM. The physiology of wound healing.J. Wound Care20009629930010.12968/jowc.2000.9.6.2599411933346
    [Google Scholar]
  21. LawrenceW.T. Physiology of the acute wound.Clin. Plast. Surg.199825332134010.1016/S0094‑1298(20)32467‑69696896
    [Google Scholar]
  22. HuntT.K. HopfH. HussainZ. Physiology of wound healing.Adv. Skin Wound Care2000132Suppl.61111074996
    [Google Scholar]
  23. DiegelmannR.F. EvansM.C. Wound healing: an overview of acute, fibrotic and delayed healing.Front. Biosci.200491-328328910.2741/118414766366
    [Google Scholar]
  24. ServoldS.A. Growth factor impact on wound healing.Clin. Podiatr. Med. Surg.1991849379531933739
    [Google Scholar]
  25. BaumC.L. ArpeyC.J. Normal cutaneous wound healing: clinical correlation with cellular and molecular events.Dermatol. Surg.200531667468610.1097/00042728‑200506000‑0001115996419
    [Google Scholar]
  26. GreenhalghD.G. The role of apoptosis in wound healing.Int. J. Biochem. Cell Biol.19983091019103010.1016/S1357‑2725(98)00058‑29785465
    [Google Scholar]
  27. ClarkR.A.F. Regulation of fibroplasia in cutaneous wound repair.Am. J. Med. Sci.19933061424810.1097/00000441‑199307000‑000118328509
    [Google Scholar]
  28. LeachM.J. Calendula officinalis and wound healing: A systematic review.Wounds Evidence-Based Compl Alter Med2008208236243
    [Google Scholar]
  29. FronzaM. HeinzmannB. HamburgerM. LauferS. MerfortI. Determination of the wound healing effect of Calendula extracts using the scratch assay with 3T3 fibroblasts.J. Ethnopharmacol.2009126346346710.1016/j.jep.2009.09.01419781615
    [Google Scholar]
  30. DindaM. DasguptaU. SinghN. BhattacharyyaD. KarmakarP. PI3K-mediated proliferation of fibroblasts by Calendula officinalis tincture: Implication in wound healing.Phytother. Res.201529460761610.1002/ptr.529325641010
    [Google Scholar]
  31. DindaM. MazumdarS. DasS. GangulyD. DasguptaU.B. DuttaA. JanaK. KarmakarP. The water fraction of Calendula officinalis hydroethanol extract stimulates In Vitro and In Vivo proliferation of dermal fibroblasts in wound healing.Phytother. Res.201630101696170710.1002/ptr.567827426257
    [Google Scholar]
  32. ParenteL.M.L. Lino JúniorR.S. TresvenzolL.M.F. VinaudM.C. de PaulaJ.R. PauloN.M. Wound healing and anti-inflammatory effect in animal models of Calendula officinalis L. growing in Brazil.Evid. Based Complement. Alternat. Med.201220121710.1155/2012/37567122315631
    [Google Scholar]
  33. Shivananda NayakB. Sivachandra RajuS. OretteF.A. Chalapathi RaoA.V. Effects of Hibiscus rosa sinensis L (Malvaceae) on wound healing activity: A preclinical study in a Sprague Dawley rat.Int. J. Low. Extrem. Wounds200762768110.1177/153473460730284017558005
    [Google Scholar]
  34. AdhirajanN. Ravi KumarT. ShanmugasundaramN. BabuM. In vivo and in vitro evaluation of hair growth potential of Hibiscus rosa-sinensis Linn.J. Ethnopharmacol.2003882-323523910.1016/S0378‑8741(03)00231‑912963149
    [Google Scholar]
  35. AliAA JusohNH Evaluation of Hibiscus rosa-sinensis leaves extracts as wound healing promoter on rats.2014 IEEE Conference on Biomedical Engineering and Sciences (IECBES)Kuala Lumpur, Malaysia201435235510.1109/IECBES.2014.7047519
    [Google Scholar]
  36. KhanZ.A. NaqviS.A. MukhtarA. HussainZ. ShahzadS.A. ManshaA. AhmadM. ZahoorA.F. BukhariI.H. Ashraf-JanjuaM.R. MahmoodN. YarM. Antioxidant and antibacterial activities of Hibiscus Rosa-sinensis Linn flower extracts.Pak. J. Pharm. Sci.201427346947424811803
    [Google Scholar]
  37. ShenH.M. ChenC. JiangJ.Y. ZhengY.L. CaiW.F. WangB. LingZ. TangL. WangY.H. ShiG.G. The N-butyl alcohol extract from Hibiscus rosa-sinensis L. flowers enhances healing potential on rat excisional wounds.J. Ethnopharmacol.201719829130110.1016/j.jep.2017.01.01628088494
    [Google Scholar]
  38. ShangX. PanH. LiM. MiaoX. DingH. Lonicera japonica Thunb.: Ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine.J. Ethnopharmacol.2011138112110.1016/j.jep.2011.08.01621864666
    [Google Scholar]
  39. LiY. CaiW. WengX. Lonicerae Japonicae Flos and Lonicerae Flos: a systematic pharmacology review.Evidence-Based Complem Alter Med2015201516
    [Google Scholar]
  40. ChenW.C. LiouS.S. TzengT.F. LeeS.L. LiuI.M. Wound repair and anti-inflammatory potential of Lonicera japonica in excision wound-induced rats.BMC Complement. Altern. Med.201212122610.1186/1472‑6882‑12‑22623173654
    [Google Scholar]
  41. YangD. XuJ. ShiR. Root extractive from Daphne genkwa benefits in wound healing of anal fistula through up-regulation of collagen genes in human skin fibroblasts.Biosci. Rep.2017372BSR2017018210.1042/BSR2017018228396516
    [Google Scholar]
  42. BangK.K. YunC.Y. LeeC. JinQ. LeeJ.W. JungS.H. LeeD. LeeM.K. HongJ.T. KimY. HwangB.Y. Melanogenesis inhibitory daphnane diterpenoids from the flower buds of Daphne genkwa.Bioorg. Med. Chem. Lett.201323113334333710.1016/j.bmcl.2013.03.09623623417
    [Google Scholar]
  43. MortonJ.F. Folk uses and commercial exploitation of Aloe leaf pulp.Econ. Bot.196115431131910.1007/BF02907852
    [Google Scholar]
  44. RubinM.B. Vitamins and wound healing.Plast. Surg. Nurs.198441161910.1097/00006527‑198400410‑000036562658
    [Google Scholar]
  45. DavisR.H. LeitnerM.G. RussoJ.M. ByrneM.E. Wound healing. Oral and topical activity of Aloe vera.J. Am. Podiatr. Med. Assoc.1989791155956210.7547/87507315‑79‑11‑5592607423
    [Google Scholar]
  46. SalehiB. AlbayrakS. AntolakH. KręgielD. PawlikowskaE. Sharifi-RadM. UpretyY. Tsouh FokouP. YousefZ. Amiruddin ZakariaZ. VaroniE. SharopovF. MartinsN. IritiM. Sharifi-RadJ. Aloe genus plants: from farm to food applications and phytopharmacotherapy.Int. J. Mol. Sci.2018199284310.3390/ijms1909284330235891
    [Google Scholar]
  47. LawrenceR. TripathiP. JeyakumarE. Isolation, purification and evaluation of antibacterial agents from Aloe vera.Braz. J. Microbiol.200940490691510.1590/S1517‑8382200900040002324031440
    [Google Scholar]
  48. Martínez-RomeroD. AlburquerqueN. ValverdeJ.M. GuillénF. CastilloS. ValeroD. SerranoM. Postharvest sweet cherry quality and safety maintenance by Aloe vera treatment: A new edible coating.Postharvest Biol. Technol.20063919310010.1016/j.postharvbio.2005.09.006
    [Google Scholar]
  49. HajiaghaalipourF. KanthimathiM. S. AbdullaM. A. SanusiJ. Effect of Camellia sinensis on wound healing potential in an animal model.Evidence-Based Complementary and Alternative Medicine201320137
    [Google Scholar]
  50. HsuS. BollagW.B. LewisJ. HuangQ. SinghB. SharawyM. YamamotoT. SchusterG. Green tea polyphenols induce differentiation and proliferation in epidermal keratinocytes.J. Pharmacol. Exp. Ther.20033061293410.1124/jpet.103.04973412663686
    [Google Scholar]
  51. KlassB.R. BranfordO.A. GrobbelaarA.O. RolfeK.J. The effect of epigallocatechin-3-gallate, a constituent of green tea, on transforming growth factor-β1–stimulated wound contraction.Wound Repair Regen.2010181808810.1111/j.1524‑475X.2009.00552.x20002896
    [Google Scholar]
  52. SyedF. BagabirR.A. PausR. BayatA. Ex vivo evaluation of antifibrotic compounds in skin scarring: EGCG and silencing of PAI-1 independently inhibit growth and induce keloid shrinkage.Lab. Invest.201393894696010.1038/labinvest.2013.8223835737
    [Google Scholar]
  53. ParkG. YoonB.S. MoonJ.H. KimB. JunE.K. OhS. KimH. SongH.J. NohJ.Y. OhC. YouS. Green tea polyphenol epigallocatechin-3-gallate suppresses collagen production and proliferation in keloid fibroblasts via inhibition of the STAT3-signaling pathway.J. Invest. Dermatol.2008128102429244110.1038/jid.2008.10318463684
    [Google Scholar]
  54. AsadiS.Y. ParsaeiP. KarimiM. EzzatiS. ZamiriA. MohammadizadehF. Rafieian-kopaeiM. Effect of green tea (Camellia sinensis) extract on healing process of surgical wounds in rat.Int. J. Surg.201311433233710.1016/j.ijsu.2013.02.01423459184
    [Google Scholar]
  55. KimH. KawazoeT. HanD.W. MatsumaraK. SuzukiS. TsutsumiS. HyonS.H. Enhanced wound healing by an epigallocatechin gallate-incorporated collagen sponge in diabetic mice.Wound Repair Regen.200816571472010.1111/j.1524‑475X.2008.00422.x19128267
    [Google Scholar]
  56. SubapriyaR. NaginiS. Medicinal properties of neem leaves: a review.Curr. Med. Chem. Anticancer Agents20055214915610.2174/156801105317482815777222
    [Google Scholar]
  57. SiddiquiB.S. AliS.T. RajputM.T. GulzarT. RasheedM. MehmoodR. GC-based analysis of insecticidal constituents of the flowers of Azadirachta indica A. Juss.Nat. Prod. Res.200923327128310.1080/1478641080200608219235028
    [Google Scholar]
  58. BaruaCC. TalikdarA. Evaluation of the wound healing activity of methonolic extract of Azadirachta Indica and Tinospora Cordifolia in rats.Pharmacologyonline201017077
    [Google Scholar]
  59. ChundranN.K. HusenI.R. RubiantiI. Effect of neem leaves extract (Azadirachta Indica) on wound healing.Althea Medical Journal20152219920310.15850/amj.v2n2.535
    [Google Scholar]
  60. AlamP. ShakeelF. AnwerM.K. FoudahA.I. AlqarniM.H. Wound healing study eucalyptus essential oil containing nanoemulsion in rat model.J. Oleo Sci.201867895796810.5650/jos.ess1800530012898
    [Google Scholar]
  61. VelmuruganC. Wound healing potential of leaves of eucalyptus citriodoralin rats.World J. Pharm. Sci.2014216271
    [Google Scholar]
  62. NezhadF.M. Antibacterial activity of Eucalyptus extracts on methicillin resistance Staphylococcus aureus.Res. J. Biol. Sci.200948905908
    [Google Scholar]
  63. HukkeriV.T. KaradiR.V. Wound healing property of Eucalyptus globulus leaf extract.Indian Drugs.200239481483
    [Google Scholar]
  64. BautistaD.M. SigalY.M. MilsteinA.D. GarrisonJ.L. ZornJ.A. TsurudaP.R. NicollR.A. JuliusD. Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels.Nat. Neurosci.200811777277910.1038/nn.214318568022
    [Google Scholar]
  65. ZhangM. WangJ. ZhuL. Zanthoxylum bungeanum Maxim. (Rutaceae): A systematic review of its traditional uses, botany, phytochemistry, pharmacology, pharmacokinetics, and toxicology.Int. J. Mol. Sci.20171810217210.3390/ijms1810217229057808
    [Google Scholar]
  66. ArtariaC. MaramaldiG. BonfigliA. RiganoL. AppendinoG. Lifting properties of the alkamide fraction from the fruit husks of Zanthoxylum bungeanum.Int. J. Cosmet. Sci.201133432833310.1111/j.1468‑2494.2010.00629.x21284659
    [Google Scholar]
  67. EmeruwaA.C. Antibacterial substance from Carica papaya fruit extract.J. Nat. Prod.198245212312710.1021/np50020a0027097295
    [Google Scholar]
  68. DawkinsG. HewittH. WintY. ObiefunaP.C. WintB. Antibacterial effects of Carica papaya fruit on common wound organisms.West Indian Med. J.200352429029215040064
    [Google Scholar]
  69. HouQ. HeW.J. HaoH.J. HanQ.W. ChenL. DongL. LiuJ.J. LiX. ZhangY.J. MaY.Z. HanW.D. FuX.B. The four-herb Chinese medicine ANBP enhances wound healing and inhibits scar formation via bidirectional regulation of transformation growth factor pathway.PLoS One2014912e11227410.1371/journal.pone.011227425489732
    [Google Scholar]
  70. HouQ. HeW.J. ChenL. HaoH.J. LiuJ.J. DongL. TongC. LiM.R. ZhouZ.Z. HanW.D. FuX.B. Effects of the four-herb compound ANBP on wound healing promotion in diabetic mice.Int. J. Low. Extrem. Wounds201514433534210.1177/153473461557524425795279
    [Google Scholar]
  71. WalshM.E. ReisD. JonesT. Integrating complementary and alternative medicine: Use of myrrh in wound management.J. Vasc. Nurs.201028310210.1016/j.jvn.2010.06.00120709267
    [Google Scholar]
  72. GuptaA. KumarR. UpadhyayN. PalK. KumarR. SawhneyR. Effects of Rhodiola imbricata on dermal wound healing.Planta Med.200773877477710.1055/s‑2007‑98154617611935
    [Google Scholar]
  73. MishraK.P. GanjuL. SinghS.B. Anti-cellular and immunomodulatory potential of aqueous extract of Rhodiola imbricata rhizome.Immunopharmacol. Immunotoxicol.201234351351810.3109/08923973.2011.63830722239552
    [Google Scholar]
  74. GuptaV. LahiriS.S. SultanaS. TulsawaniR.K. KumarR. Anti-oxidative effect of Rhodiola imbricata root extract in rats during cold, hypoxia and restraint (C–H–R) exposure and post-stress recovery.Food Chem. Toxicol.20104841019102510.1016/j.fct.2010.01.01220079793
    [Google Scholar]
  75. SenthilkumarR. ChandranR. ParimelazhaganT. Hepatoprotective effect of Rhodiola imbricata rhizome against paracetamol-induced liver toxicity in rats.Saudi J. Biol. Sci.201421540941610.1016/j.sjbs.2014.04.00125313275
    [Google Scholar]
  76. GoelH.C. BalaM. PrasadJ. SinghS. AgrawalaP.K. SwahneyR.C. Radioprotection by Rhodiola imbricata in mice against whole-body lethal irradiation.J. Med. Food20069215416010.1089/jmf.2006.9.15416822199
    [Google Scholar]
  77. SenthilkumarR. ParimelazhaganT. ChaurasiaO.P. SrivastavaR.B. Free radical scavenging property and antiproliferative activity of Rhodiola imbricata Edgew extracts in HT-29 human colon cancer cells.Asian Pac. J. Trop. Med.201361111910.1016/S1995‑7645(12)60194‑123317880
    [Google Scholar]
  78. MenS. HuoQ. ShiL. YanY. YangC. YuW. LiuB. Panax notoginseng saponins promotes cutaneous wound healing and suppresses scar formation in mice.J. Cosmet. Dermatol.202019252953410.1111/jocd.1304231267657
    [Google Scholar]
  79. Sabouri-RadS. Sabouri-RadS. SahebkarA. Tayarani-NajaranZ. Ginseng in dermatology.Curr. Pharm. Des.201723111649166610.2174/138161282266616102115232227774902
    [Google Scholar]
  80. YuanX. HanL. FuP. ZengH. LvC. ChangW. RunyonR.S. IshiiM. HanL. LiuK. FanT. ZhangW. LiuR. Cinnamaldehyde accelerates wound healing by promoting angiogenesis via up-regulation of PI3K and MAPK signaling pathways.Lab. Invest.201898678379810.1038/s41374‑018‑0025‑829463877
    [Google Scholar]
  81. GanasoundariA. Uma DeviP. RaoB.S.S. Enhancement of bone marrow radioprotection and reduction of WR-2721 toxicity by Ocimum sanctum.Mutat. Res.1998397230331210.1016/S0027‑5107(97)00230‑39541656
    [Google Scholar]
  82. MedirattaP.K. SharmaK.K. SinghS. Evaluation of immunomodulatory potential of Ocimum sanctum seed oil and its possible mechanism of action.J. Ethnopharmacol.2002801152010.1016/S0378‑8741(01)00373‑711891082
    [Google Scholar]
  83. PrakashP. GuptaN. Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: A short review.Indian J. Physiol. Pharmacol.200549212513116170979
    [Google Scholar]
  84. PattanayakP. BeheraP. DasD. PandaS. Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview.Pharmacogn. Rev.2010479510510.4103/0973‑7847.6532322228948
    [Google Scholar]
  85. GoelA. KumarS. SinghD.K. BhatiaA.K. Wound healing potential of Ocimum sanctum Linn. with induction of tumor necrosis factor-alpha.Indian J. Exp. Biol.201048440240620726339
    [Google Scholar]
  86. HanumaJ.B. MishraA.K. SabataB. A natural phenolic lignin from Tinospora Cordifolia miers.J. Chem. Soc.1986111811186
    [Google Scholar]
  87. AkbikD. GhadiriM. ChrzanowskiW. RohanizadehR. Curcumin as a wound healing agent.Life Sci.201411611710.1016/j.lfs.2014.08.01625200875
    [Google Scholar]
  88. TejadaS. ManayiA. DagliaM. NabaviS.F. SuredaA. HajheydariZ. GortziO. Pazoki-ToroudiH. NabaviS.M. Wound healing effects of curcumin: A short review.Curr. Pharm. Biotechnol.201617111002100710.2174/138920101766616072112310927640646
    [Google Scholar]
  89. Turmeric for HealthHow Turmeric Aids in Wound Healing.Turmeric for Health
    [Google Scholar]
  90. BaligaM.S. BhatH.P. JosephN. FazalF. Phytochemistry and medicinal uses of the bael fruit (Aegle marmelos Correa): A concise review.Food Res. Int.20114471768177510.1016/j.foodres.2011.02.008
    [Google Scholar]
  91. JagrutiS Bael as a potential medicinal tree: an overview.World J. Pharm Res.111114061414
    [Google Scholar]
  92. ArunachalamK.D. S. Subhashini, and S. K. Annamalai. “Wound healing and antigenotoxic activities ofAegle marmelos with relation to its antioxidant properties.”.J. Pharm. Res.20125314921502
    [Google Scholar]
  93. JaswanthA. LoganathanV. ManimaranS. Wound healing activity of Aegle marmelos.Indian J. Pharm. Sci.2001634144
    [Google Scholar]
  94. GautamM.K. In vivo healing potential of Aegle marmelos in excision, incision, and dead space wound models.The Scientific World Journal20142014
    [Google Scholar]
  95. VidyaiS.M KrishnaV. ManjunathaB.K. Evaluation of wound healing activity of root an dleaf extracts of Clerodendrum serratum L.Indian Drugs200542609613
    [Google Scholar]
  96. Kameswara RaoB. GiriR. KesavuluM.M. ApparaoC. Effect of oral administration of bark extracts of Pterocarpus santalinus L. on blood glucose level in experimental animals.J. Ethnopharmacol.2001741697410.1016/S0378‑8741(00)00344‑511137350
    [Google Scholar]
  97. KondetiV.K. BadriK.R. MaddiralaD.R. ThurS.K.M. FatimaS.S. KasettiR.B. RaoC.A. Effect of Pterocarpus santalinus bark, on blood glucose, serum lipids, plasma insulin and hepatic carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats.Food Chem. Toxicol.20104851281128710.1016/j.fct.2010.02.02320178824
    [Google Scholar]
  98. ArokiyarajS. MartinS. PerinbamK. MarieA.P. BeatriceV. Free radical scavenging activity and HPTLC finger print of Pterocarpus santalinus L. – an in vitro study.Indian J. Sci. Technol.20081713[Google Scholar].10.17485/ijst/2008/v1i7.3
    [Google Scholar]
  99. NarayanS. DeviR.S. SrinivasanP. DeviC.S.S. Pterocarpus santalinus: A traditional herbal drug as a protectant against ibuprofen induced gastric ulcers.Phytother. Res.2005191195896210.1002/ptr.176416317653
    [Google Scholar]
  100. YoganarasimhanS.N. Bangalore: Cyber Media.Tamil NaduMedicinal Plants of India200063
    [Google Scholar]
  101. ChoJ.Y. ParkJ. KimP.S. YooE.S. BaikK.U. ParkM.H. Savinin, a lignan from Pterocarpus santalinus inhibits tumor necrosis factor-alpha production and T cell proliferation.Biol. Pharm. Bull.200124216717110.1248/bpb.24.16711217086
    [Google Scholar]
  102. EvansM. A guide to herbal remedies.Orient Paperbacks1994
    [Google Scholar]
  103. VickersA. ZollmanC. ABC of complementary medicine: Herbal medicine.BMJ199931972161050105310.1136/bmj.319.7216.105010521203
    [Google Scholar]
  104. KaushikK. AgarwalS. Role of herbal antifungal agents for the management of fungal diseases: A systematic review.Asian J Pharm. Clin. Res.20191273440
    [Google Scholar]
/content/journals/cis/10.2174/2210299X01666230120120814
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  • Article Type:
    Review Article
Keyword(s): Blood cells; Cytokines; Growth factors; Plant extract; Regeneration; Wound healing
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