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- Volume 19, Issue 6, 2024
Current Drug Therapy - Volume 19, Issue 6, 2024
Volume 19, Issue 6, 2024
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Molecular Contrivance of Deed of Neuroprotective Biomolecules
Authors: Rashmi S. Pal, Yogendra Pal, Jaspreet Lagah, Deepti Katiyar and Saranya PunniyakottiNumerous herbal-based Ayurvedic and Chinese medications contain a variety of phytochemicals that may have a neuroprotective impact and help treat a variety of neurodegenerative diseases. The natural medicinal drug has long been used to treat neural signs and symptoms. There has been an enormous public and clinical interest in the use of Phytoconstituents for neuroprotection or the prevention of neurodegenerative illne Read More
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Auvelity: A New Era in Medicine - Unraveling the Multifaceted Benefits of Dextromethorphan/Bupropion Combination
Authors: Anchal Dhawan, Sunayna Choudhary, Sumeet Gupta, Abhishek Chander and Meenakshi DhanawatBackground: Depression is a prevalent global illness, impacting 280 million people worldwide, and Major Depressive Disorder (MDD) is ranked as the third leading cause of disease burden globally. People previously diagnosed with depression are more likely to develop Alzheimer's disease (AD). The recent approval of Auvelity by the FDA has made a remarkable breakthrough in drug development, offering a multi-dimensional ap Read More
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Enhanced Solubility and Increased Bioavailability with Engineered Nanocrystals
Authors: Reetika Sood, Deepali Tomar, Peeyush Kaushik, Prerna Sharma, Nidhi Rani, Kumar Guarve, Sanchit Dhankhar and Nitika GargThe exploration of nanocrystal technology is currently receiving significant attention in various fields, including therapeutic formulation, clinical formulation, in-vivo and in-vitro correlation research, and related investigations. The domain of nanocrystals in pharmaceutical delivery has received significant interest as a potential solution for the difficulties associated with medications that have low solubility. The nanocryst Read More
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A Critical Assessment of Remdesivir
Authors: Subhash Chandra, Alka N. Choudhary, Santwana Palai, Abdur Rauf and Hassan Y. Aboul-EneinThe COVID-19 pandemic that originated in Wuhan city, China, has affected every village in India. This has killed millions of people. This disease involves symptomatic and asymptomatic mutations. The purpose of this review was to assess the effectiveness of remdesivir particularly against SAR-CoV-2 (Coronaviridae family). The relevant works have been studied with respect to the drug's chemistry, mechanism of action, pha Read More
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Unlocking the Potential of Drug Delivery Systems: A Comprehensive Review of Formulation Strategies and Technologies in the Field of Pharmaceutics
Authors: Nitin Rajan and Shubham KanaujiyaThe creation of innovative drug delivery systems to enhance therapeutic effectiveness, safety, and patient compliance has resulted in considerable developments in pharmaceutics in recent years. The most recent formulation techniques and technologies are reviewed in this article to improve medication distribution and accomplish specific therapeutic goals. This article thoroughly summarizes the most recent formulation techn Read More
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Prospective Approaches of Herbal Novel Delivery System with Special Reference to the Herbal Nanosciences
Authors: Kartikay Prakash and Shashank TiwariMedicinal and culinary uses of plants date back centuries. Projects on a global scale are conducting laboratory research to identify plants with therapeutic properties, with the ultimate goal of developing such compounds into medicines with acceptable drug delivery mechanisms and bringing them to market. Non-synthetic medications derived from plant or herbal sources have attracted a lot of interest because of the Read More
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Current Advances and Applications of Diagnostic Microfluidic Chip: A Review
Authors: Garima Katyal, Anuj Pathak, Parul Grover and Vaibhav SharmaBackground: As a developed technology, microfluidics now offers a great toolkit for handling and manipulating suspended samples, fluid samples, and particles. A regular chip is different from a microfluidic chip. A microfluidic chip is made of a series of grooves or microchannels carved on various materials. This arrangement of microchannels contained within the microfluidic chip is connected to the outside by inputs and o Read More
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Evaluation of Phytochemicals, Antioxidants, and Antidiabetic Activity of Nitophyllum marginale by Using Analytical Approaches
Authors: Rohit Malhotra and Louis CojandarajBackground: Nitophyllum marginale holds potential for medical applications due to its bioactive compounds, making it promising for developing new therapeutic interventions. Our study aims to evaluate the bioactivity of Nitophyllum marginale extracts obtained using methanol and chloroform solvents. We focus on analyzing the phytochemical profile, antioxidant activity, and antidiabetic potential of seaweed extract Read More
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Melatonin Alleviates High Glucose-induced Oxidative Stress and Mitochondrial Dysfunction in Chondrocytes
Authors: Saeed Mehrzadi, Shokoufeh Hassani and Azam HosseinzadehBackground: Hyperglycemia triggers mitochondrial dysfunction in chondrocytes, potentially contributing to cell damage and the onset of osteoarthritis. Objective: This study is undertaken with the objective of examining the protective properties of melatonin against toxicity induced by high glucose in C28I2 human chondrocytes. Methods: To determine non-cytotoxic concentrations of melatonin, various concentrations (1 Read More
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Formulation, Design, Optimization, and Characterization of Novel Long-acting Injectable Dosage Form of Anti-psychotic Drug
Authors: Niraj Patel, Rakesh Patel and Abhay DharamsiBackground: The current research aimed to create and analyze a new long-acting Brexpiprazole (BRX) injectable for successful anti-psychotic drug therapy in order to decrease dosage frequency and increase patient compliance. Systems for drug transport to particular body sites or regulating release rates with accuracy are known as drug delivery systems (DDS). By affixing the drug to a carrier particle like liposomes, nanoparti Read More
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Detection of Iturin A from Bacillus atrophaeus by HPLC and Mass Spectrometry Analysis and Evaluation of its Antifungal Activity
Authors: Solmaz M. Pisheh, Mahboobeh Madani and Pegah ShakibBackground: Bacillus species create several kinds of metabolites, which contain cyclic lipopeptide-type antibiotics, consisting of three major families: fengycin, surfactin, and iturin. Iturin demonstrates powerful biocontrol characteristics and can restrain the growth of a diversity of plant fungal pathogens. Objective: The current study investigates the identification of iturin A from Bacillus atrophaeus using HPLC and Mass s Read More
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QSAR Studies on Thienopyrimidines as Potential Antimicrobial Agents
Authors: Pranali A. Jadhav and Pratiksha JadhavBackground: Recent research has revealed promising antibacterial action for thienopyrimidines. To comprehend the underlying molecular features underlying their antibacterial potency, a thorough quantitative structure-activity relationship (QSAR) investigation is required. Objectives: In order to clarify the structural parameters for effective antibacterial activity, we conducted QSAR analyses on a variety of thienopyrimidines in thi Read More
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Volumes & issues
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Volume 20 (2025)
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Volume 19 (2024)
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Volume 18 (2023)
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Volume 17 (2022)
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Volume 16 (2021)
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Volume 15 (2020)
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Volume 14 (2019)
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Volume 13 (2018)
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Volume 12 (2017)
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Volume 11 (2016)
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Volume 10 (2015)
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Volume 9 (2014)
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Volume 8 (2013)
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Volume 7 (2012)
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Volume 6 (2011)
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Volume 5 (2010)
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Volume 4 (2009)
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Volume 3 (2008)
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Volume 2 (2007)
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Volume 1 (2006)
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