Current Drug Therapy - Volume 19, Issue 3, 2024

Psoriasis is a chronic immune-mediated skin disorder affecting millions worldwide. The pathogenesis of psoriasis involves dysregulated immune responses characterized by aberrant activation of T cells and proinflammatory cytokines. Immunomodulation has emerged as a promising therapeutic approach for managing psoriasis, aiming to restore immune homeostasis. However, despite significant advancements, chall Read More

The pharmaceutical industry grows every year keeping public health as a priority, protection, and economic development. The industry is mostly concentrated on the novel drug development process as well as new methods that can help improve the recovery rate of a condition and improve the quality of patient treatment. Pharmaceutical companies have recently experimented with producing medications using 3D printing t Read More

Background: Rheumatoid arthritis affects roughly 5 out of every 1000 persons, rheumatoid arthritis is a persistent anarchic ailment with complicated pathophysiology a well-known cause of arthritis- related stinging apropos nexus, degradation of synovium, the creation of pannus, damage to bones, and loss of the cartilage. Thus, it is imperative to diagnose and treat rheumatoid arthritis. Due to rheumatoid arthritis' Read More

Background: The comprehension of the molecular, cellular, and biological mechanisms that underlie the management of the sleep-wake cycle, as well as the effects of circadian disruption on health and illness, has made significant strides. Methods: An extensive literature review was done from the standard databases such as Scopus, Elsevier, and PubMed using standard keywords “Circadian rhythm”, and “sleep disorders”. In thi Read More

Multi drug-resistant or extensive drug resistance Mycobacterium tuberculosis poses numerous challenges for health care workers and for public health authorities. Treating multidrug resistant or extensive drug resistance tuberculosis continues to be a difficult task, as a longer regimen is associated with a higher number of adverse drug events and economic burden and has a significant negative effect on health care reso Read More

Background: Nanoemulsions (N.E.s) capable of ocular bioavailability elevation can be used for poor water-soluble drugs such as ketoconazole (K.Z.). The current investigation was designed for the purpose of overcoming this issue by developing K.Z. containing N.E.s for ophthalmic drug delivery with appropriate therapeutic efficiency. Methods: The preparation of ketoconazole N.E.s was performed by the low-energy technique. Ac Read More

Background: Brimonidine tartrate is currently used to treat glaucoma; however, conventional ocular formulations have some disadvantages in terms of treating disorders like glaucoma, as less than 5% of the drug reaches a posterior segment of the eye; hence, there is a need for sustained treatment. Objective: The objective of this study was to develop a self-nanoemulsion (SNEDDS) in-situ gel of brimonidine tartrate to inve Read More

Background: Thyroid dysfunction is one of the most important side effects of lithium carbonate. Silymarin is a flavonolignan extracted from the milk thistle Silybum marianum (L.), which has remarkable antioxidant and therapeutic properties. This clinical trial study aimed to evaluate the effect of silymarin on thyroid function and serum antioxidant status in patients with lithium-treated bipolar disorder. Methods: Bipolar patients wit Read More

Background: The improper or incorrect usage of birth control results in unintended pregnancy. In India, 78% of pregnancies are accidental, with unwanted pregnancies accounting for about 25% of all pregnancies. The family, society, and country may all be financially impacted by such pregnancies. Community pharmacists must have a good attitude and sufficient knowledge of emergency contraception pills (ECPs) in or Read More

Introduction: Pemphigus is a group of autoimmune dermatological life-threatening diseases of which Pemphigus Vulgaris (PV) is the most common (1-5 cases/million/year) with a mortality rate of 60-90%. PV is generally characterized by painful oral erosions, along with or without cutaneous lesions, as blisters are often misdiagnosed. The management strategy of PV includes steroids along with adjuvant therapy. Case Present Read More