Current Drug Therapy - Volume 19, Issue 4, 2024

The coronavirus outbreak (COVID-19, SARS-CoV-2) greatly impacts the world. Despite great biomedical efforts, approximately 30-50% global population was at least once infected with COVID. Human life expectancy is reduced by COVID-19 epidemics worldwide. It is indispensable to prevent and treat COVID-19 as effectively as possible. In order to well prevent and treat the coronavirus infection, clinical diagnostic or t Read More

Gastric cancer is the fourth leading cause of morbidity worldwide and is known to affect various gastric organs, including the esophagus, intestine, colon, and pancreas. There are variable factors responsible for the development of gastric tumors, such as environmental factors, EPV, hepatitis B and C, and other genetic factors. Phytoactives, or secondary metabolites of plants, have a wide range of biological impacts, including th Read More

Background: Intravenous immunoglobulin (IVIG), as an expensive medication under a national shortage, has been widely used for the treatment of several autoimmune diseases and immunodeficiency syndromes. Although conducting studies on therapeutic indications of IVIG has increased significantly, a limited number of researches have investigated individualized dosing in terms of the drug, disease state, and some patie Read More

Background: Growing public awareness of chronic pain resulting from illness and injury has prompted pharmaceutical researchers and drug corporations to create better, more targeted painkillers. For effective pain management, prolonged analgesic medication delivery at the intended areas continues to be a major problem such as addiction, tolerance and other serious side effects, which can prolong suffering and decr Read More

Nanoscale machines called “nanorobots” that were hitherto only futuristic ideas are set to storm healthcare and pharmaceuticals with newer technologies for minimally invasive diagnosis, quick and precise surgeries, and targeted drug delivery, which is challenging to achieve by conventional drug delivery systems. Nanobots can be defined as controllable nano-sized mechanical or electromechanical devices which Read More

In recent years, microparticulate systems have drawn growing attention as a viable strategy for delivering cells, proteins, and medications to target areas. The Nanoparticles-in-Microparticles System (NiMS) is a drug delivery method that combines nano- and microparticles to deliver medications or genes to particular bodily regions with precision. A promising method for achieving dual or multiple functions inside a formulation is t Read More

Background: Polycystic ovary syndrome (PCOS) is a reproductive, metabolic, and endocrine disorder with unclear aetiology. PCOS, the most common cause of female reproductive and metabolic disorders, is known to affect more than one in ten women globally. PCOS and associated clinical manifestations are probably underdiagnosed despite their high occurrence. Objectives: Alternative animal models have been em Read More

Leprosy is curable and can be treated with multidrug therapy in the early stages. As a result, we chose a Scientometrics evaluation of leprosy research guides on adverse drug reactions to better grasp the current popularity of drug-related responses. During the 2010-2021 a study with a total of 48 publications was selected. This study aims to analyze scientometric tools such as frequency distribution, percentage analysis, Read More

Background: Dendrobium chrysotoxum Lindl. is an important medicinal plant of the genus Dendrobium from the Orchidaceae family. Gigantol is one of the key bioactive phytochemicals found in Dendrobium plants. Gigantol is reported to have diverse pharmacological activities. Aims: This narrative review explores the analytical aspects along with pharmacological activities of gigantol as reported in different scientific public Read More

Background: The defining features of dry eye syndrome, a frequent tear and ocular surface multifactorial disorder, are changes in the ocular surface epithelia linked with less tear production and elevated sensitivity of the ocular surface, which trigger an inflammatory response. Aqueous deficit dry eye and evaporated dry eye are the two common types of dry eye. A few of the testing methods used to detect Dry Eye Dise Read More

Background: Increased levels of oxidative stress are connected with depression. Due to the melatonin's antioxidant effects and Vitamin D3 (Vit D3)'s regulatory effect on the biosynthesis of neurotransmitters and neurotrophic factors, the present study investigated the possible protective effect of melatonin and Vit D3 combination on restraint stress-induced depression-like behaviors in mice. Methods: After being subjected Read More

Background: Marine sediments are rich sources for isolating active secondary metabolites from microorganisms. Among the microorganisms, Actinomycetes are highly important due to the production of various chemical compounds in a wide range of biological activities, such as antibacterial activity. Streptomyces is the most important genera in the family of Actinomycetes. As a member of this group, it has great Read More