Current Chemical Biology - Volume 18, Issue 3, 2024

BackgroundDiabetic retinopathy (DR) is the leading cause of vision loss in diabetic patients. Currently, the treatment involves the use of glucocorticoids or a VEGF antagonist, which are “off-label” at present. However, the conventional method of drug discovery and development is a time-consuming process that requires more than a decade of meticulous research and huge financial support. While there are a few eff Read More

IntroductionThe brain is highly susceptible to oxidative damage due to excessive oxygen tension, a high concentration of oxidizable substrates, and low antioxidant capacity. Consequently, oxidative stress is linked to several brain disorders and neurodegeneration. Sodium azide is a cytochrome oxidase inhibitor that promotes neurodegeneration by enhancing the release of excitotoxins and inducing oxidative stress through the p Read More

BackgroundPhosphorylated α-Synuclein (α-Syn) is present in relatively small levels in normal human brains, but nearly all of the α-Syn in the Lewy bodies (LBs) that collect in the nigrostriatal region in the brain of Parkinson's disease patients is phosphorylated on serine 129 (pS129). Earlier studies suggested that mimicking phosphorylation at S129 may have an inhibitory effect on α-Syn aggregation and thus control α-Syn n Read More

BackgroundPyrazolyl-pyrimidinone derivatives are important heterocyclic compounds. A novel HIV-1 (human immunodeficiency virus type 1) inhibitors based on these components were designed as potential drug candidates for AIDS (acquired immunodeficiency syndrome) therapy.ObjectiveThis research aims to develop a predictive mathematical model linking the biological activity and physicochemical prop Read More

BackgroundChalcones have been demonstrated to possess numerous therapeutic qualities in recent years, such as antibacterial, antiviral, anti-ulcerative, antioxidant, anti-inflammatory, antihyperglycemic, antimalarial, antitubercular, analgesic, antiplatelet, and anticancer activities.ObjectiveTo explore the synthesis, docking, and therapeutic characteristics of chalcones as antibacterial and anthelmintic com Read More