Current Chemical Biology - Volume 18, Issue 2, 2024

Brain cancers, particularly gliomas, are a significant cause of mortality worldwide. Gliomas are primary tumors of the central nervous system (CNS) and are characterized by diverse clinical and biological features. Despite advancements in clinical approaches and surgical techniques, the treatment of high-grade gliomas still poses multiple challenges. This article focuses on a key active substance found in Panax ginseng ca Read More

BackgroundsLeukemic stem cells are considered to be the main cause of treatment failure and disease recurrence due to their resistance to most common therapies. Apoptosis induction is one of the highly effective methods for treating cancer. Ciprofloxacin is among the compounds whose antitumor effects have been confirmed.ObjectivesIn this study, we investigated the anti-proliferative effect and induction of apoptosis by Read More

ObjectiveNanoparticles (NPs) are reliable biological tools for curative purposes through their application in nanomedicine. The present study synthesized and characterized silver nanoparticles (AgNPs) from Tetrapetra tetrapleura fruit. The investigation aims to examine the antidiabetic effect of the AgNPs using in vitro and in vivo models.MethodsBriefly, the synthesized AgNPs were confirmed by the application of ultravi Read More

BackgroundThe allelopathic effects of the essential oils of M. piperita and C. coronarium on seed germination of two wheat species qualify them as bio-herbicides.ObjectiveIn order to search for natural plant-based products that may have herbicidal action, we selected two plant species, M. piperita and C. coronarium, to evaluate the allelopathic potential of their essential oils on wheat seed germination of two wheat species. Read More

BackgroundNumerous natural products have been successfully developed for clinical use in the treatment of human diseases in almost every therapeutic area.ObjectivesThis work aimed to assess the in-vitro and in-silico α-amylase inhibition activities of carlina oxide and aplotaxene, isolated from the roots of Carthamus caeruleus and Rhaponticum acaule respectively.MethodsThe essential oil from C. caeruleus roots Read More

BackgroundAcute Kidney Injury (AKI) is a common clinical disease that has a high incidence and mortality rate. Clove, a robust natural source of bioactive chemicals and rich in secondary metabolites, plays a wide range of biological roles.AimThe present study aimed to assess the ameliorative efficacy of clove extract against acute renal damage induced by folic acid in rats.MethodsGas Chromatography/Mass Spect Read More