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Current Chemical Biology - Online First
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Recent Advances in Chemistry and Biological Activity of Aromatase Inhibitors
Authors: Mahmoud N.M. Yousif and Ameen A. Abu-HashemAvailable online: 12 February 2025More LessDifferent aromatase inhibitors are available in the market as anticancer agents. However, the market still needs new drugs for treating cancer due to several side effects of the available drugs. There is a continuous effort from researchers to discover new aromatase inhibitory agents. This editorial summarizes recent studies describing the synthesis and biological activities of promising aromatase inhibitors.
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Innovative Nitrogen-Based Heterocycles: Pioneering Advances in Anticancer Therapeutics
Authors: Anuradha Mehra, Amit Mittal and Rekha SangwanAvailable online: 20 January 2025More LessStructural diversity, pharmacological relevance, and the ability to include N-containing heterocyclic derivatives through medicinal chemistry make these heterocyclic compounds known as essential scaffolds for the design and development of anticancer agents. Uncontrolled cell proliferation with metastasis remains a leading cause of global mortality from cancer. Enzyme binding sites interact with compounds with N-heterocy Read More
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Echinochrome-A Attenuates Arterial Thrombosis Complications in the Liver and Kidney in Rats
Available online: 24 December 2024More LessBackground Arterial thrombosis represents the most commonly feared consequence of cardiovascular disease and a leading cause of death globally. Cardiovascular disease, liver, and kidney are closely linked conditions, and disease in one organ can lead to dysfunction in the other. Objective The current research aims to examine the therapeutic impact of Ech-A on arterial thrombosis induced by FeCl3 complications Read More
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Influence of Chromium(VI) on the Environment and Metabolic Processes in the Body
Authors: Bohdan Kotyk and Ruslana IskraAvailable online: 23 December 2024More LessCr(VI) is a heavy metal characterized by potent toxic, carcinogenic, mutagenic, and prooxidant properties. Cr(VI) is one of the eight metals that are among the most toxic compounds and are of great concern to scientists due to the global risk to human health. In recent years, Cr(VI) has attracted the attention of environmental researchers due to the increased level of ecosystem contamination by Cr compounds in many Read More
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Integrating Deep Learning and Molecular Dynamics to Identify GPR17 Ligands for Glioblastoma Therapy
Available online: 17 December 2024More LessBackground Guanine Protein-coupled Receptor 17 (GPR17) plays pivotal roles in various physiological processes and diseases. However, the discovery of ligands binding to GPR17 remains an active area of research. Methods In this study, we utilized our recently published GPCR-specific deep learning approach, molecular docking, and molecular dynamics simulations. Specifically, the DeepGPCR model, employing graph c Read More
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Evaluation of Antioxidant Properties and Antihyperlipidemic Activity of Phytochemicals in Luffa acutangula Leaves
Authors: Shahzadi Bano, Jamal Akhtar Ansari, Farogh Ahsan and Abdul Rahman KhanAvailable online: 17 December 2024More LessBackground Hyperlipidaemia, characterized by elevated triglyceride and cholesterol levels in the blood, is linked to premature aging and degenerative diseases, often driven by free radicals. Antioxidants can help address these issues by neutralizing free radicals. Luffa acutangula leaves are known for their antioxidant properties due to their content of flavonoids and phenolic compounds. Objective This study aimed Read More
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Intestinal Anti-Inflammatory and Antioxidant Potential of Arthrospira platensis Aqueous Extract on DNBS-Induced Colitis in BALB/c Mice
Authors: Meriem Aziez, Noureddine Bribi, Mohamed Sofiane Merakeb, Riad Ferhat and Safia AffenaiAvailable online: 16 October 2024More LessBackground The most common Inflammatory Bowel Diseases (IBD) affecting the gastrointestinal system are Crohn's disease and ulcerative colitis. However, the usual therapies for them are associated with a multitude of side effects. The blue-green microalgae Arthrospira platensis is known for its safety profile, nutritional, and medicinal properties in the treatment of different inflammatory and gastrointestinal disorders. Objectiv Read More
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In-vitro and In-silico α-amylase Inhibition Activity of Carlina Oxide and Aplotaxene Isolated From the Roots of Carthamus caeruleus and Rhaponticum acaule
Available online: 02 October 2024More LessBackground Numerous natural products have been successfully developed for clinical use in the treatment of human diseases in almost every therapeutic area. Objectives This work aimed to assess the in-vitro and in-silico α-amylase inhibition activities of carlina oxide and aplotaxene, isolated from the roots of Carthamus caeruleus and Rhaponticum acaule respectively. Methods The essential oil from C. caeruleus roots Read More
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