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image of Biogenic Silver Nanoparticles (AgNPs) Ameliorates Oxidative Biomarkers in Type-2 Diabetic Rats: In vitro and In vivo Report

Abstract

Objective

Nanoparticles (NPs) are reliable biological tools for curative purposes through their application in nanomedicine. The present study synthesized and characterized silver nanoparticles (AgNPs) from a fruit. The investigation aims to examine the antidiabetic effect of the AgNPs using and models.

Methods

Briefly, the synthesized AgNPs were confirmed by the application of ultraviolet-visible (UV-Vis) spectroscopy, and five other techniques, ; transmission electron microscopy (TEM) techniques, Fourier transform infrared (FTIR) spectroscopy, energy dispersive X-ray spectroscopy (EDX), X-ray diffraction analysis (XRD) and scanning electron microscope (SEM). The model assay investigated the scavenging effect of AgNPS on (DPPH), superoxide anion (Oˉ), hydroxyl anion (-OH), ferric reducing antioxidant power (FRAP), and α-amylase/α-glucosidase inhibitory activity. The model involving rats-induced type-2 diabetes with streptozotocin (STZ) was divided into six (6) groups of seven (7) rats each to assess antioxidative parameters.

Results

The AgNPs scavenged free radicals (DPPH) and moderately inhibited (Oˉ), hydroxyl anion (-OH), reduced ferric to ferrous ions, and inhibited both α-amylase and α-glucosidase activity with increasing concentrations. Similarly, AgNPs ameliorated oxidative stress imposed by type 2 diabetes on the rats’ tissues significantly ( < 0.05), depleting total cholesterol, low-density lipoprotein (LDL), and increased total protein composite and high-density lipoprotein (HDL) contents. The AgNPs enhanced catalase and superoxide dismutase, reduced glutathione (GSH), and, concomitantly, decreased malondialdehyde (MDA) levels in the tissue homogenate.

Conclusion

These findings provide scientific evidence for the first time, finding the application of a biogenic compound synthesized from fruit in the treatment of type 2 diabetes.

© 2024 Bentham Science Publishers
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2024-10-04
2024-11-22

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/content/journals/ccb/10.2174/0122127968284847240920103341
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Biogenic Silver Nanoparticles (AgNPs) Ameliorates Oxidative Biomarkers in Type-2 Diabetic Rats: In vitro and In vivo Report
Bentham Science Publishers ; https://doi.org/10.2174/0122127968284847240920103341
/content/journals/ccb/10.2174/0122127968284847240920103341
/content/journals/ccb/10.2174/0122127968284847240920103341
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  • Article Type:     Research Article
Keywords: type 2- diabetes ; inhibition ; streptozotocin ; Nanoparticles ; T. tetrapleura ; spectroscopy ; scavenging

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