Current Bioactive Compounds - Volume 20, Issue 2, 2024

Background: Antimicrobial resistance against pathogenic bacterial strains is the current problem faced by the world. Medicinal plants are being focussed for new alternatives to routine antibiotics for novel therapeutic and antimicrobial approaches. Objective: In this present study, fennel extract from Foeniculum vulgare plant was investigated against methicillin-resistant Staphylococcus aureus (MRSA). Method: Ethanol ext Read More

Background: Depression is one of the most common neurological disorders for which only symptomatic treatment is available with synthetic drugs with serious side effects. Allicin [S- (2-propenyl)-2-propene-1-sulfinothioate] is a bioactive component derived from Allium sativum L. (Garlic). It has the property to penetrate the blood-brain barrier, which reveals its neuroprotective property. A synthetic drug named fluoxetine (selecti Read More

Background: Glycosylamine play an important role in living organisms. Most plants store their chemical resources in the form of inactive glycosides, which are broken down and converted into sugar in the body of herbivores by hydrolyzing enzymes. Glycosylamine are obtained from the secondary metabolism of plants and consist of two parts. One part of it contains sugar like glucose and is inactive in most substances, a Read More

Piperazine is the heterocyclic nucleus and exhibits significant biological potential such as antipsychotic, antidepressant, antihistamine, anticancer, anti-anginal, cardioprotective, antiviral, and anti-inflammatory activity. As a result, it had been considered a crucial structural component in the majority of the therapeutic medications that were already on the market. Other issues that limit its use include solubility, limited bioavail Read More

Background: One-pot synthesis of new and biologically important betulinic acid derivatives has been designed and efficiently achieved in this work. Methods: The utilization of the carboxylic and hydroxyl moieties of betulinic acid has resulted in the development of a one-pot strategy towards the synthesis of some target compounds. Results: One-pot synthesis of new betulinic acid derivatives 3-9 has been achieved in moderate to Read More

Background: Pyrazolidine 5,3-dione derivatives have a wide range of biological and pharmacological activities and play an important role in the sub-structures of various drugs. They also have inhibitory and antimicrobial properties, anti-tumor, anti-inflammatory, analgesic, antituberculosis, anti-hypertensive, anti-cancer, and anti-Alzheimer. The purpose of the current study was to investigate a number of synthesis methods of py Read More

Background: Curcumin, a polyphenol compound, is reported to exhibit ameliorative effects in acute lung injury and different organ fibrosis models. We have previously demonstrated that curcumin, at a dose of 75 mg/kg, could modulate inflammatory mediators and fibrinolytic system proteins in the inflammatory stage as well as fibroproliferative stage in a mouse model of bleomycin (BLM) induced pulmonary fibrosis. In this study Read More

Background: Arsenic is a potent environmental toxin with dangerous effects on human and animal populations. Heteroxenia fuscescens (H. fuscescens) extract exhibits potential health effects. The purpose of this study was to assess the protective effect of H. fuscescensextract against sodium arsenite-induced infertility and toxicity in rats. Methods: Forty male rats were separated into four groups as follows: control grou Read More

Bioactive peptides derived from soybeans have recently been identified as having potential health benefits for preventing and curing cancer and cardiovascular disorders. This narrative review focuses on the potential role of these peptides in such conditions and the possible mechanisms by which they may act. Soybean-derived bioactive peptides have been found to possess anti-tumor, antioxidant, anti-inflammatory, and ch Read More

Aims: The study aimed to search of new molecular complexes of licorice saponin with fluoroquinolone antibiotics and to explore their pharmaceutical potential. Background: Molecular complexation of triterpene glycosides with pharmaceutical substances reduces side effects and therapeutic doses, increases bioavailability and stability, and expands the spectrum of biological activity of drugs. Glycyrrhizic acid is the Read More