Current Bioactive Compounds - Volume 20, Issue 4, 2024

Background: Breast cancer was known as the second most common cause of death in the world, natural sources compound derived from milk thistle called silymarin had already shown anticancer properties. Objective: In the present study, silymarin was used to treat MCF7 cells and inhibition of stem cell pluripotency genes, as well as cell proliferation. Methods: MCF7 cells were cultured in the presence of RPMI-1640 Read More

Aims: Bixin and norbixin are natural antioxidants used as pigments in the food industry, but their chemical structure makes them susceptible to environmental factors (light, oxygen, and temperature). Background: Nanoencapsulation techniques can improve the stability and solubility of these compounds in addition to reducing particle size which can increase the surface-to-volume ratio and provide many attractive and u Read More

Background: Nuclear enzyme poly (ADP-ribose) polymerase-1 (PARP-1) controls the cell cycle, DNA repair, transcription, and replication processes. In this study, olaparib and rucaparib have been taken as standard drugs for comparison of results. As per previous research data, 1,3,4-Oxadiazole moiety has multidirectional biological activity and shows high activity against cancer. Objective: This study aimed to carry out the in silic Read More

Epigenetics deals with the changes in gene expression (no change in the genetic code) concerning certain epigenetic elements in response to the environment. Some of the most common epigenetic examples include DNA methylation, histone modifications, and non-coding RNAs. This field has been extensively applied in forensic studies, particularly to determine types of body fluids, distinguish them from mixed samples, uncove Read More

Alzheimer’s disease (AD) is the most common neurodegenerative and progressive disorder that results in damage to memory and alters thinking and behavior, which represent critical problems the world’s aging population is faced with. Clinical symptoms of AD include cognitive decline, loss of memory, emotional and behavioral changes, loss of motor coordination, and mental impairments. Yet, neither a universally accepted di Read More

Cancer remains a leading cause of death worldwide, with traditional chemotherapy treatments causing significant side effects. Short synthetic peptides have emerged as a potential alternative due to their unique properties, including selectivity, stability and biocompatibility. Recent research has shown that short peptides can act as effective anticancer agents through their ability to inhibit the COX-2 (Cyclooxegenase-2) enzym Read More

Introduction: Etoricoxib is a BCS class II drug with poor aqueous solubility and analgesic and anti-inflammatory properties. Complexation with cyclodextrins is one of the widely used methods, amongst others, for enhancing the solubility and bioavailability of drugs. In current research work, inclusion complexes of etoricoxib using modified forms of cyclodextrin, i.e., captisol were prepared using kneading, evaporation, and fre Read More

Background: Sideritis species were used for the treatment of mental disorders such as Alzheimer’s and dementia traditionally in Turkey. Several in vivo studies report that the mid-polar extract of Sideritis species can develop the brain functions of mice. 2-β-hydroxy manoyl oxide, isolated from ethyl acetate extract of Sideritis perfoliata, was assayed in vitro and in silico on human erythrocytes CA I and CA II. The compound was f Read More

Background: Ruta montana (R. montana) is a medicinal plant with a long history of traditional use in treating ailments. Objective: The present work aims to study the phytochemical composition and to evaluate the biological activities of R. montana L. (Rutacea) extracts. Methods: Bioactive compounds were obtained using solid-liquid extraction using solvents of increasing polarity. The obtained extracts were qualitatively anal Read More