Current Bioactive Compounds - Volume 20, Issue 6, 2024

Background: One of the most crucial heterocycles is piperazine for the creation of novel medication candidates with a variety of medicinal applications. The piperazine moiety is a cyclic compound with four carbon atoms and two nitrogen atoms in positions 1 and 4. Objective: The objective of this studty is the development of 1-((3,4-dimethoxyphenyl) (substitutedphenyl) substituted -piperazine (A1-A10) analogs via t Read More

Chalcone is a bioactive flavonoid found in various plants, such as Angelica archangelica, Pueraria lobata, and Glycyrrhiza glabra. It has been studied extensively in the field of pharmaceutical sciences due to its significant role in therapeutic potential including antibacterial, antiinflammatory, analgesic, cytotoxic, and antitumor properties. A plenty of study indicated numerous chalcone derivatives exhibit enhanced potency and Read More

Background: One of the main risk factors for atherosclerosis is hypercholesterolemia. Objective: This study aimed to assess hypercholesterolemia's effect on the liver, heart, and kidney and the impact of Syngonium podophyllum L. leaves methanolic extract as a treating agent in a rat model. Methods: Flavonoid components were isolated and identified from the methanolic extract of Syngonium podophyllum L. leaves. Total ser Read More

Objectives: The study aimed to assess the neuroprotective effect of Boswellia serrata against 3-NP-induced experimental Huntington's disease. Background: Previous studies have shown Boswellia to have sedative, analgesic, and anti-tumour effects. Boswellia serrata yields four pentacyclic triterpene acids and boswellic acid, a bioactive substance that prevents leukotriene biogenesis. Methods: The potential neuroprotective Read More

Objective: To study the cytotoxic effect of palmitic acid on myoblasts in vitro and the influence of this toxicant on the expression of myostatin mRNA in myoblast culture. Methods: To research the protective action against these processes of a compound with antioxidant activity, for which 2-ethyl-6-methyl-3-hydroxypyridine malate (ethoxidol) was chosen. Results: Our studies have shown that palmitic acid has a noticeable cytostati Read More

Background: Helicobacter Pylori is widely present in human populations, making it one of the most common bacteria found in humans. Due to the drug's side effects, extensive research is being done to find new effective nanoparticles against Helicobacter Pylori in the world. Therefore, this systematic review aims to investigate nanoparticles' antimicrobial activities against Helicobacter Pylori. Methods: All articles published fr Read More