Current Bioactive Compounds - Volume 20, Issue 9, 2024

Background: Infectious diseases are considered a global public health problem, with viruses being the predominant infectious agents afflicting the human population. The most used control alternatives are the search and development of vaccines and drugs. Nevertheless, their efficacy has limitations related to the immune response stimulation, resistance mechanisms, costeffort ratio, development, and production. An alter Read More

The octahedral Pt(IV) complexes contain either inert or biologically active ligands where the nature of these axial ligands provides additional stability and synergistic biological activity. There are many literature reports from each of the classes mentioning the varied nature of these axial ligands. The targeting, as well as the non-targeting nature of these moieties, exerts additive or synergistic effects of anticancer activity Read More

Background: Obsessive-Compulsive Disorder (OCD) is a common psychiatric illness characterized by obsessions or compulsions that significantly disrupt or impair daily functioning. Coleus forskohlii, a significant medicinal crop, has forskolin in its roots. It is utilized extensively as food and medicine all over the world. Coleus forskohlii has reputed medicinal uses, which include antidepressant, antiaggregant, cAMP-genic, anti Read More

The intriguing role of the oxidation system in cardiovascular disease lies in its contribution to chronic and acute increases in intracellular reactive oxygen species (ROS), driving the progression of cardiovascular diseases (CVDs). ROS, produced as by-products of oxidative physiological and metabolic events, act as mediators in various signaling pathways contributing to cardiovascular pathology. The delicate equilibrium betw Read More

Introduction: This paper aimed to investigate, for the first time, the possibility of increasing the antibacterial activities of thymol (TH) by developing an encapsulating agent based on chitosan-grafted cyclodextrin. For this purpose, β-cyclodextrin was monosubstituted at position 6 via propargyl bromide, and chitosan's amine groups were converted to azide functions. After alkylation and diazotization reactions, the grafting of β-c Read More