Current Bioactive Compounds - Volume 18, Issue 9, 2022

Background: Inflammatory response is the body’s first-line defence mechanism in which the immune system recognises, counters the antigens, and aids in healing the disease. The World Health Organisation suggests that inflammation is one of the greatest causes of death in the world. Inflammation could be acute or chronic due to the release of inflammatory mediators, i.e. prostaglandins, leukotrienes due to mitogens, Read More

Background: Sanguinarine, a benzophenanthridine alkaloid extracted from Sanguinaria canadensis has been found to show an inhibitory role on proapoptotic and growth inhibitory activities in various tumor cells of experimental subjects. Objective: This review highlights and summarizes the effects of sanguinarine against cancers alongside the possible mechanisms involved as depicted in various in vitro and in vivo models. R Read More

Natural products have stimulated the interest of chemists owing to their abundant structural diversity and complexity. Indeed, natural products have performed an essential role, particularly in the cure of cancerous and infectious diseases, thereby providing medicinal researchers with several unexplored chemotypes for the innovation of new drugs. Fusion of chemical derivatization and combinatorial synthesis forms th Read More

Objectives: the synthesis of 4-((1-phenyl-3-(substitutedphenyl)-1h-pyrazol-4-yl) methylene)- 4h-pyrazol-3,5-diamine and 3-amino-4-((1-phenyl-3-(substitutedphenyl)-1h-pyrazol-4-yl) methylene)-1h-pyrazol-5(4h)-one was designed and performed very aptly in deep eutectic solvent system. Methods: the utilization of deep eutectic solvent (des) system chcl/gly (1:2) in the absence of hazardous organic co-solvents, an efficient Read More

Background: Buriti (Mauritia flexuosa) oil has high economic potential because it contains monounsaturated and polyunsaturated fatty acids with high antioxidant potential and high carotenoid content, making it an excellent source of pro-vitamin A. Objective: The objective of this work was to evaluate the rheological properties of filmogenic solutions incorporated with different buriti oil concentrations. Methods: Buriti oil (0.15 t Read More

Background: Chalcones are open-chain flavonoids especially attractive to medicinal chemistry due to their easy synthesis and the possibility of structural modifications. Objective: This study aims to evaluate the in vitro anticancer activity of a series of hybrids chalcones- thiosemicarbazones against the human hepatocellular carcinoma cell line HepG2. Methods: Seven hybrid chalcones-thiosemicarbazones (CTs), 3-(4’-X-phenyl Read More

Thiazole and the related nuclei constitute one of the most significant moieties in the extensively emerging domain of heterocyclic compounds. The versatile nature of the thiazole nucleus can be determined as it is present in natural products like vitamin B1. Furthermore, its derivatives exhibit diverse biological activities, including antimicrobial, anticancer, antihistaminic, antioxidant, etc. They have also emerged as potent CNS Read More