Current Bioactive Compounds - Volume 18, Issue 10, 2022

Background: Diabetes has become a considerably more frequent condition and has increased alarmingly in recent years, possibly due to the adoption of modern lifestyle and food habits. The two prominent features of diabetes mellitus are high blood glucose and insulin deficiency, leading to severe consequences. Developing next-generation anti-diabetic medicines with fewer side effects has been a major focus in this situa Read More

Background: Traditional medicine has used Mimosa pudica Linn. for diabetes treatment. This study evaluates the antidiabetic and renoprotective effects of the ethyl acetate fraction of M. pudica leaves on streptozotocin-induced diabetes in mice. Methods: The cold maceration method was used to extract M. pudica leaves with 80% ethanol at room temperature. Ethyl acetate (EtOAc) fraction was obtained from the M. pudic Read More

Background: Heterocyclic compounds possess a wide variety of roles in most fields of science, such as biochemistry, medicinal chemistry, veterinary products, agrochemicals, etc. Triazole, a heterocycle compound, serves as a building block for various compounds having multiple applications, mostly in medicine. Triazole is a five-membered ring containing compounds that occur in nature, found in several microorg Read More

Background: This study aimed to isolate and analyse the essential oils of Eugenia caryophyllus flower buds and Citrus reticulata peels for antioxidant and antibacterial properties. Methods: By using the DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) free radical method and the ferric reducing antioxidant power (FRAP) method, the antioxidant activities of total volatile oil components of both oils were assessed. Agar we Read More

Background: Aristolochia longa L. (Aristolochiaceae), known as Berreztam, is frequently used in traditional medicine to manage several diseases and has been the subject of several studies. However, its inhibitory effect on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) has not yet been reported. Thus, the present work aimed to study the anticholinesterase and antioxidant activities of extracts from different par Read More

Background: Peganum harmala L. is a medicinal herbal plant widely used in traditional medicine in various countries, especially in Algeria. This study aimed to carry out the extraction of P. harmala seeds and to evaluate the antioxidant and antihemolytic potentials of 100 mg/kg methanol extract in plasma, blood, and liver of Swiss albino mice. Methods: The antioxidant capacity of the plasma samples was performed using f Read More

Background: Aquatic organisms are considered to be an important source of bioactive peptides with a high antioxidant and antihypertensive capacity. Therefore, the objective of this study was to hydrolyse peptide fractions from white shrimp (Litopenaeus vannamei) muscle by Alcalase and Protamex and to evaluate the angiotensin I-converting enzyme (ACE) inhibitory and the antioxidant activities. Methods: Protein hydr Read More

Background: Schiff bases are organic compounds and play a vital role in making biologically active compounds in various fields of chemistry. It shows antioxidant, antidepressant, antimalarial, anti-inflammatory, antiglycation, and antimicrobial activity. Objective: Our current study is focused on synthesizing thirty-four 2-mercaptobenzimidazole (MBI) based novel hydrazone derivatives (9-42) which were examined for antioxida Read More

Background: Chalcone and flavone moieties play an important role in medicinal chemistry for the development of potential therapeutic agents. These two derivatives serve a wide range of applications in recent studies and are promising lead molecules for the synthesis of compounds with vast therapeutic utility for many diseases, particularly for cancer therapy. Objective: The present review focused on the fact that chalco Read More