Current Bioactive Compounds - Volume 18, Issue 7, 2022

Microbial resistance towards antibiotics has become a global threat to human health. There is currently an urgent need to develop novel antibacterial and antifungal agents with new mechanisms of antimicrobial action and lower levels of toxicity. This paper reviews the structureactivity relationship as well as the antimicrobial effect of substituted rhodanine derivatives. The inhibitory effects of the substitu Read More

Tuberculosis (TB) is a life-threatening infectious disease caused by the bacteria Mycobacterium tuberculosis (MTB), which mostly affects the lungs. According to the World Health Organization (WHO) report 2020, there were over 10 million cases of tuberculosis worldwide, with around 1.4 million people dying, wherein India accounts for over 26% of the global burden. Prolonged treatment, high pill burden, low compliance, develop Read More

Background: Herbal plants have been used in medicine for the treatment of numerous human health complications. Plant-derived products, including extract, botanicals, and preparations, have been used in medicine and other allied health sectors since a very early age and have been available in the market for several decades. Flavonoids have been a well-known class of phytochemicals in medicine due to their anti-oxi Read More

Background: Alzheimer’s disease (AD) is a chronic and prevalent neurodegenerative disease that leads to memory loss, especially in the elderly. AD is caused by a lack of acetylcholine in the brain and oxidative stress. The Cyamopsis tetragonoloba, also known as Guar or cluster bean, is a legume that belongs to the family Fabaceae. It is cheap, widely consumed as a seasoned vegetable, and reported to counteract chronic disease Read More

Introduction: This work aimed to create a new platinum-interferon conjugate and investigate its properties. Background: Multiple drug resistance of tumor cells is a serious challenge in modern medicine. Neoplastic diseases are often complicated by persistent bacterial infections, which impairs efficacy and the outcome of anticancer therapy. The development of new bifunctional drugs for the treatment of tumor growth and bact Read More

Background: Xanthomonas axonopodis pv. citri is a gram-negative bacterium that affects citrus crops, causing a disease known as citrus canker. Although essential oils and other compounds isolated from plants represent a natural alternative to treat this disease, they have the disadvantage of having low solubility in the media in which the bioassays to determine antimicrobial activity are performed. This has led several resea Read More

Background: Thymol is a bioactive compound having many pharmacological activities. Objective: The present study was carried out to evaluate the fungi toxic effects of thymol and derivatives against phytopathogenic fungi of maize. Methods: Thymol was derivatized to get formylated thymol, Mannich bases, and imine derivatives. All the synthesized thymol derivatives were characterized by their physical and spectral propertie Read More

Background: Plants are an abundant natural source of potential chemical compounds; they have been widely used in various industries, such as pharmaceuticals, cosmetics, and food. This work aims to study two Saharan medicinal plants by evaluating the activity of plant extract against bacterial and fungal plant pathogens as well as against the model nematode Caenorhabditis (C.) elegans. Methods: The antimicrobial ac Read More

Background: The main aim of the study was to compare the neuroprotective potential of Polyherbal Formulation (PHF) with that of an extract of a well-reported anti-parkinson plant, i.e., Mucuna pruriens. Methods: Different PHF combinations (PHFs) were formulated by using hydro-alcoholic extracts and were tested for neuroprotective potential against Mucuna pruriens extract (MPE). In the experimental study, 30 albino mice Read More