Current Bioactive Compounds - Volume 18, Issue 2, 2022

Background: An enhanced knowledge of the multiple effects of ascorbic acid (AA) in health can broaden our understanding of the impacts of its deficiency. Methods: Mice (10-12 month old) were either fed standard rodent feed or AA-fortified diet at 100, 200 and 300 mg/kg of feed, respectively for 8 weeks. On completion of the study, animals were sacrificed, following which haematological, inflammatory/apoptotic Read More

Background: New 6-hydroxy-5-(p-hydroxybenzylidene)-3-phenyl-2- [(5-pchlorophenyl)- 1,3-thiazol-2-yl]-1, 2, 4-triazine derivatives containing a thiazole ring were synthesised as potential antitumor agents. Methods: Cytotoxicity of compounds (3) and (4) was evaluated in human hepatocellular carcinoma (HCC) cell lines (HepG2); compound (3) showed more cytotoxicity (IC50=9.0μg/ml) than compound (4) (IC50= Read More

Background: The fruits, leaves and roots of Morinda species are used in the treatment of inflammations, cancers, diabetes, psychiatric disorders, bacterial and viral infections. However, no study has been conducted on chemical profiling, anti-inflammatory, antioxidant and antimicrobial potentials of leaves of seven Indian Morinda species. Aim: The study aimed to investigate the anti-inflammatory, antioxidant and antimic Read More

Introduction: Progress in the development of triazolyl-oxadiazoles, a bisphosphonate- 700 inhibitor, is still continuing with an outcome of the good scaffold as oxadiazole as well as triazoles individually for antibacterial activity. Hence, we have proposed a suitable approach for the synthesis of dual heterocyclic analogues consisting of the therapeutically used non-steroidal anti- inflammatory drugs in a combined form and evalu Read More

Background: Background: Lycium europaeum L. is a medicinal and edible Mediterranean halophyte spiny shrub, however, studies regarding its biological properties focused mainly on its aerial organs. Objective: The objective of the present work was to make a comparative evaluation of the in vitro antioxidant and enzyme inhibitory activities of ethanol extracts and fractions (chloroform, ethyl acetate, n-butanol and aqueous) Read More

Background: Considering that many foreign tourists visit Okinawa, Japan, to purchase cosmetic products, there is an urgent need to create cosmetic products native to Okinawa. As the Ryukyu pine tree, which is endemic to Okinawa, has been used as a source of wood, investigating the possible use of its bark is recommended. Using this natural resource from Okinawa would aid in promoting the products of Okinawa’s un Read More

Background: The treatment of diabetes involves insulin and many different oral hypoglycemic drugs. In chronic disease conditions, medications potentially lose viability. Therefore, searching for more effective and safer natural anti-diabetic agents has continued to be an important area of investigation. Objective: The present study aims to investigate the effect of ethanolic and aqueous extracts of Schleichera oleosa (S. ole Read More