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Volume 1, Issue 1
  • ISSN: 2666-1217
  • E-ISSN: 2666-1225

Abstract

Linn has been used as a traditional medicine to treat various ailments, including snakebite. It is found in India, Ceylon and Thailand.

The study was performed to determine the inhibiting potential of methanolic leaf extract on the pharmacological effects of Viper venom.

The dose-dependent enzymatic studies, pharmacological and studies were conducted using standard methods.

It neutralized toxic enzymes in a dose-dependent manner with concentrations ranging from 53.3 –1190.4 μg/mL, inhibited lysis of fibrinogen at 1:8 (venom: extract, w/w), and increased the procoagulant activity and lecithin lysis at 1:25 (venom: extract, w/w). The extract neutralized the LD of venom in mice and embryos, reduced haemorrhage, myotoxicity and edema induced by the venom in mice.

The observed results confirm that the leaf extract possesses adequate phytochemicals that could neutralize the toxic properties of the venom.

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2021-03-01
2025-02-17

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/content/journals/vat/10.2174/2666121701999201216144752
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Inhibitory Effect of Carissa spinarum Linn Methanolic Leaf Extract Against Vipera russelli
Ven and Tox 1, 85 (2021); https://doi.org/10.2174/2666121701999201216144752
/content/journals/vat/10.2174/2666121701999201216144752
/content/journals/vat/10.2174/2666121701999201216144752
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  • Article Type:     Research Article
Keyword(s): Carissa spinarum Linn; fibrinogenolysis; haemorrhage; In vivo; snake bite; Vipera russelli

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