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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Stabilization of Folding Intermediate States from Alkaline Induced Unfolded State of Bovine Serum Fetuin in Trifluoroethanol and Acetonitrile
- Source: Protein and Peptide Letters, Volume 17, Issue 5, May 2010, p. 660 - 666
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- 01 May 2010
Abstract
The conformation of bovine serum fetuin (BSF) was examined over the pH 7.0-12.9 regions by circular dichroism, intrinsic fluorescence and ANS binding. We observed that at higher pH, BSF exists in alkaline unfolded state. Our results provided evidence that correlates simultaneous formation of secondary structure followed by accumulation of hydrophobic clusters.
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