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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Sonication Induced Intermediate in Prion Protein Conversion
- Source: Protein and Peptide Letters, Volume 15, Issue 2, Feb 2008, p. 206 - 211
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- 01 Feb 2008
Abstract
We have observed that hamster prion protein (PrPC) undergoes conformational changes on exposure to heat or sonication. If a sonication induced new conformer is seeded with a small amount of its abnormal pathogenic isoform (PrPSc) it undergoes a significant conversion to a proteinase-resistant isoform. This suggests the presence of a third stable PrP conformer, which may be intermediate in the conversion of PrPC to PrPSc.
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