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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Redox State of Cytochrome c Regulates Cellular ROS and Caspase Cascade in Permeablized Cell Model
- Source: Protein and Peptide Letters, Volume 15, Issue 2, Feb 2008, p. 200 - 205
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- 01 Feb 2008
Abstract
In a permeablized cell system, oxidized cyt c is able to induce caspase cascade whereas reduced cyt c cannot. In in vitro experiments, oxidized cyt c can promote H2O2 generation. It is suggested that the redox state of cyt c might regulate the initiation of apoptosis via regulation of cellular ROS level.
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