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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Stability of Synthetic Exendin-4 in Human Plasma In Vitro
- Source: Protein and Peptide Letters, Volume 14, Issue 1, Jan 2007, p. 19 - 25
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- 01 Jan 2007
Abstract
Sites of exendin-4 that that are relatively susceptible to degradation in plasma were identified with the aim of providing information for designing new exendin-4 analogues. The stability of exendin-4 in human plasma was evaluated in vitro. The results showed that the peptide was slowly degraded with a half-life of 9.57 h and the principal cleavage sites are between Thr5 and Phe6, Phe6 and Thr7, and Thr7 and Ser8 of the N-terminus region of exendin-4.
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