Influence of Human B-Casomorphin-7 on Specific Binding of 3H-Spiperone to the 5-HT2-Receptors of Rat Brain Frontal Cortex

Oleg Y. Sokolov; Natalya V. Kost; Yurii A. Zolotarev; Ekaterina N. Ryukert; Andrey A. Zozulya

doi:10.2174/092986606775101733

ISSN: 0929-8665
E-ISSN: 1875-5305

Influence of Human B-Casomorphin-7 on Specific Binding of 3H-Spiperone to the 5-HT2-Receptors of Rat Brain Frontal Cortex
Authors: Oleg Y. Sokolov¹, Natalya V. Kost², Yurii A. Zolotarev³, Ekaterina N. Ryukert⁴ and Andrey A. Zozulya⁵
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¹ National Research Center for Mental Health, Russian Academy of Medical Sciences, Moscow, Russia. ² National Research Center for Mental Health, Russian Academy of Medical Sciences, Moscow, Russia. ³ National Research Center for Mental Health, Russian Academy of Medical Sciences, Moscow, Russia. ⁴ National Research Center for Mental Health, Russian Academy of Medical Sciences, Moscow, Russia. ⁵ National Research Center for Mental Health, Russian Academy of Medical Sciences, Moscow, Russia.
Source: Protein and Peptide Letters, Volume 13, Issue 2, Feb 2006, p. 169 - 170
DOI: https://doi.org/10.2174/092986606775101733
- Available online: 01 Feb 2006

Abstract

Using radio-receptor analysis, it has been demonstrated that human ε-casomorphin-7 (Tyr-Pro-Phe-Val- Glu-Pro-Ile) displaces 3H-spiperone from 5-HT2-receptors of rat brain frontal cortex. IC50 of human β-casomorphin-7 was 8 μM. These data suggest that one of the mechanisms of neurotropic action of β-casomorphin-7 is might be associated with its influence on the serotoninergic system.

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2006-02-01

2025-05-21

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Article Type: Research Article

Keyword(s): 5-HT2-receptors; Human β-Casomorphin-7; spiperone

Influence of Human B-Casomorphin-7 on Specific Binding of 3H-Spiperone to the 5-HT2-Receptors of Rat Brain Frontal Cortex

Abstract

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