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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Oxidation of Goat Hepatic Galectin-1 Induces Change in Secondary Structure
- Source: Protein and Peptide Letters, Volume 10, Issue 3, Jun 2003, p. 265 - 275
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- 01 Jun 2003
Abstract
Galectin-1 requires a reducing environment for its lectin activity and the carbohydrate binding function is destroyed in oxidizing condition. In this report we provide direct evidence that the oxidation of goat hepatic galectin-1 perturbs its carbohydrate recognition domain and this could be due to changes in secondary structure of goat hepatic galectin-1. Conformational changes in goat hepatic galectin-1 due to oxidation were investigated by absorption, fluorescence and circular dichroism measurements.
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