Inhibitory And Promotive Effects Of Polyamines On Transglutaminase-Induced Protein Polymerization

Naoko Sato; Yosuke Ohtake; Hiroyuki Kohno; Shinya Abe; Yasuhito Ohkubo

doi:10.2174/0929866033478816

ISSN: 0929-8665
E-ISSN: 1875-5305

Inhibitory And Promotive Effects Of Polyamines On Transglutaminase-Induced Protein Polymerization
Authors: Naoko Sato¹, Yosuke Ohtake², Hiroyuki Kohno³, Shinya Abe⁴ and Yasuhito Ohkubo⁵
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¹ Department of Radiopharmacy, Tohoku Pharmaceutical University, 4-4-1, Komatsushima, Aoba-ku, Sendai, Miyagi 981-8558, Japan. ² Department of Radiopharmacy, Tohoku Pharmaceutical University, 4-4-1, Komatsushima, Aoba-ku, Sendai, Miyagi 981-8558, Japan. ³ Department of Radiopharmacy, Tohoku Pharmaceutical University, 4-4-1, Komatsushima, Aoba-ku, Sendai, Miyagi 981-8558, Japan. ⁴ Department of Radiopharmacy, Tohoku Pharmaceutical University, 4-4-1, Komatsushima, Aoba-ku, Sendai, Miyagi 981-8558, Japan. ⁵ Department of Radiopharmacy, Tohoku Pharmaceutical University, 4-4-1, Komatsushima, Aoba-ku, Sendai, Miyagi 981-8558, Japan.
Source: Protein and Peptide Letters, Volume 10, Issue 4, Aug 2003, p. 396 - 403
DOI: https://doi.org/10.2174/0929866033478816
- Available online: 01 Aug 2003

Abstract

Transglutaminase (TGase) has been reported to be involved in the regulation of cell growth. We examined the effects of polyamines on TGase activity. The polymerization of casein was inhibited by putrescine (PUT) and spermidine (SPD). On the other hand, polymerization of N,N-dimethylcasein was increased by spermine (SPM) and SPD. These results suggested polyamines played two distinct roles as inhibitor and promoter for TGase-catalyzed protein polymerization.

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2003-08-01

2025-05-06

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Article Type: Review Article

Keyword(s): polyamine; putrescine; spermidine; spermine; transglutaminase

Inhibitory And Promotive Effects Of Polyamines On Transglutaminase-Induced Protein Polymerization

Abstract

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