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2000
Volume 13, Issue 2
  • ISSN: 2211-7385
  • E-ISSN: 2211-7393
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Abstract

Background

Rheumatoid arthritis is indeed a constant, progressive autoimmune disease that acts on the synovial membrane, distinguished by joint pain, swelling, and tenderness. Sulfasalazine belongs to BCS Class IV having low solubility and low permeability. To overcome the issue and provide a localized effect Cubosomes were chosen for the transdermal drug delivery system.

Objectives

The primary objective of this investigation was to pass on sulfasalazine-loaded cubosomes over the skin to treat rheumatoid arthritis. On the way to overcome this issue of oral sulfasalazine and provide localized effect, Cubosomes were chosen for the transdermal drug delivery system.

Methods

Sulfasalazine-loaded cubosomes were prepared by the top-down method using GMO and Poloxamer 407. Different concentrations of lipid and surfactant were used in the formulation using 32 full factorial designs. The prepared formulations were assessed for p.s, z,p, %EE, FTIR, SEM, release, permeation, and deposition studies with pH 7.4 phosphate buffer saline.

Results

The particle size varies between 65 nm to 129 nm, while the negative zeta potential ranged from -18.8 mV to -24.8 mV. The entrapment efficiency was between 87% and 95%. The formulations' drug release was carried out for 12 hours. The optimized formulation showed a controlled release of sulfasalazine and better permeation and deposition properties than sulfasalazine suspension.

Conclusion

Overall study findings support the possibility of applying transdermal sulfasalazine-loaded cubosomes to alleviate rheumatoid arthritis.

© 2025 The Author(s). Published by Bentham Science Publishers.
 This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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2024-02-15
2025-09-08

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Development and Characterization of Sulfasalazine Cubosomes for Potential Transdermal Drug Delivery
Pharm. Nanotechnol. 13, 320 (2025); https://doi.org/10.2174/0122117385269522231113041029
/content/journals/pnt/10.2174/0122117385269522231113041029
/content/journals/pnt/10.2174/0122117385269522231113041029
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  • Article Type:     Research Article
Keyword(s): Cubosomes; glyceryl monooleate; poloxamer 407; rheumatoid arthritis; sulfasalazine; transdermal delivery

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