Natural Products Journal, The - Volume 14, Issue 4, 2024

Sophora japonica, a species of Sophora, one of the prominent genera, belongs to the family Fabaceae, native to China, which is commonly known as a pagoda tree. Sophora, includes nearly 52 species, nineteen varieties and many of these species have been used in traditional Chinese medicine to cure various ailments. This review compiles its ethnomedical uses, diverse phytochemicals reported from the various parts Read More

Phosphodiesterases (PDEs) function to hydrolyze intracellular cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), regulating a variety of intracellular signal transduction and physiological activities. PDEs can be divided into 11 families (PDE1~11) and the diversity and complex expression of PDE family genes suggest that different subtypes may have different mechanisms. PDEs are involve Read More

Osthole is a coumarin derived natural compound which is an essential ingredient of Traditional Chinese Medicine (TMC) and is widely distributed in nature in plants like Cnidium monnieri (L) Cusson and Angelica pubescens. Current study presents a critical review on description of pharmacological importance of osthole, which is reported to exhibit anticancer, antioxidant, osteogenic, hepatoprotective, neuroprotecti Read More

Background: Accumulated investigations have demonstrated that the Mariana Trench is enriched in microorganisms. However, the diversity of structures and bioactivities of the secondary metabolites produced by the Mariana Trench-associated microorganisms is poorly known, which needs to be intensively investigated. Objective: This study aimed to investigate the bioactive secondary metabolites produced by a Mariana Tre Read More

Background: Cancer is a serious disease severely endangering human health and life in the world in the world, and conventional anticancer drugs have frequently suffered from severe side effects and resistance. Therefore, developing novel and effective therapeutic strategies is urgently needed. As a Chinese herbal medicine with important medical values, Hedyotis chrysotricha has been suggested to be useful for the tre Read More

Background: Some Alstonia species are used in traditional medicine to treat diseases such as cancer, dysentery, diarrhea, jaundice, malaria, gastrointestinal troubles, and snake-bites. Objective: In this study, we aim to evaluate the ethanol leaf extract of Alstonia scholaris for anticancer constituents and structural modification to introduce a privilege medicinal α,β-unsaturated scaffold. Methods: The relative viability of the Read More