Natural Products Journal, The - Volume 14, Issue 5, 2024

Metabolic syndrome (MS) represents a complex cluster of medical conditions with profound implications for global public health. This constellation of disorders substantially increases the susceptibility to type 2 diabetes, obesity, thrombosis, cardiovascular disease, and hyperlipidemia. The drugs currently prescribed for managing MS offer limited efficacy, likely due to their limited scope of action. Owing to their restricted mechanis Read More

Objective: This study aimed to investigate the antipyretic and anti-inflammatory effects and mechanisms of Sanchen Pediatric antipyretic Paste (SPAP). Methods: Rats were randomly divided into 7 groups: negative control group, positive control group, positive treatment group, SPAP high-dose, medium-dose and low-dose groups, and blank substrate group. Except normal control group, rats in other groups were subcutane Read More

Background: Gastroduodenal ulcer is one of the common global gastrointestinal diseases. Sulongga-4 is a traditional Mongolian medicine used for the treatment of gastroduodenal ulcer. However, the molecular mechanism underlying the therapeutic effect of Sulongga-4 on gastroduodenal ulcer in the proteome has not been clarified. Objective: The purpose of this study was to explore the molecular mechanism behind the t Read More

Bacoside A is a vital bioactive component of the Indian medicinal herb Bacopa monnieri, which ranks second among the most significant medicinal plants. Bacoside A was discovered to have more pharmacological activity than bacoside B. It has been used in Ayurvedic medicine to treat mental problems and memory loss. It also possesses antioxidant, antidepressant, antiulcer, hepatoprotective, ant-cancerous, vasodilator and ot Read More

Background: Liver cirrhosis is a consequence of various chronic liver conditions and may lead to liver failure and cancer. Huangqi Decoction (HQD) is a Traditional Chinese Medicine (TCM) effective for treating liver conditions, including cirrhosis. Therefore, both the active ingredients and the pharmacological actions of HQD deserve further exploration. The active components and pharmacological actions of HQD in preventing Read More

Background: Laboratory evidence pertaining to the antihypertensive activity of a number of Ficus deltoidea (FD) varieties remains undetermined, although extracts of some of these varieties have been shown to have angiotensin-converting enzyme (ACE) inhibitory activity in vitro. Objective: This study, therefore, evaluated the effect of a standardized aqueous-ethanolic extract of leaves of Ficus deltoidea var. trengganuensis ( Read More

Background: Phyllanthus amarus exhibited immunosuppressive and anti-inflammatory effects in several in vitro and in vivo studies. However, there is no report on the inhibitory effects of its secondary metabolites on pro-inflammatory cytokines secretion from human THP-1-derived macrophages. Objective: The objective of this study was to correlate the polyphenols (ellagic acid (EA), gallic acid (GA), geraniin (GER), a Read More