Natural Products Journal, The - Volume 11, Issue 2, 2021

Diabetes remains the major public health challenge to the 21st century. It is strongly related to lifestyle changes. Most chronic complications of diabetes are macrovascular and microvascular diseases resulting from the existing hyperglycemic status. After the failure of first-line therapy, which is based on diet modifications and exercise, conventional treatment using antihyperglycemic agents with different mechanisms of Read More

Tecoma stans (L.) Juss. ex Kunth has shown potent antidiabetic effect in the past; however, none of the studies have been carried out to explore its effect in diabetic complications including diabetic retinopathy and nephropathy. Thus, this review will aim to explore and propose multiple hypotheses regarding its mechanism of action in diabetic complications which includes reduction in oxidative stress, inflammation, angio Read More

Bamboo species belonging to the Poaceae family, Poaceae has overall about 1,500 species, and 87 genera worldwide, randomly distributed between humid tropical, sub-tropical and mildmoderate regions across the globe. The plant has superior value in traditional indigenous systems of China, Ayurveda, Siddha, and Unani for its enormous medicinal and nutritional purposes since 2500 years. It was the apparent beginning Read More

Deguelin, a plant retinoid has emerged to be a promising therapeutic agent in the treatment of different cancers. Recent studies demonstrate that deguelin has potential as an angiogenesis antagonist in malignant and endothelial cells by specifically targeting HGF-c-Met and VEGFVEGFR pathways. It is reported to have profound therapeutic effects in pancreatic cancer by inactivation of the hedgehog (Hh) signalling pathw Read More

Background: Infectious diseases are responsible for millions of deaths a year worldwide. Antibiotics, which have saved so many lives and improved life expectancy, may become ineffective due to a worrying increase in bacterial resistance. Some of the appropriate actions that could be initiated to address this problem are to develop and search for new antimicrobial substances from medicinal plants, and combine antibiotics with Read More

Background: Paederia foetida (Rubiaceae) locally known as Chinese fever vine is a prominent plant species in the east and south Asia. The extract of Paederia foetida Linn. has been used for the treatment of gastric infections or other digestive disorders in Chinese traditional medicine. Objective: The main aim of the study was to isolate bioactive constituents of P. foetida stem through a bio-guided assay, then evaluate t Read More

Background: Aristolochia triangularis Cham., popularly known as the "cipó-milhomens", "angelicó" and "ypê-mi", is applied for the treatment of wounds, skin diseases (6,7), digestive and circulatory system diseases as an antipyretic and for malaria fever also. Objective: In this work, we investigated the chemical composition, the antimicrobial and antimycobacterial activities of the Essential Oils (EOs) extracted from A. tri Read More

Background: Multi-drug resistance among pathogens is emerging due to the slow pace of development of new antimicrobials by combinatorial chemistry. Natural products from microorganisms obtained from under-explored habitats can be lead molecules for such discoveries. In search of new antimicrobial compounds, Streptomyces isolate UK-201 exhibiting broad-spectrum antimicrobial and antifungal activity, obtained fr Read More

Aims: To isolate vinca alkaloid producing endophytic fungi from Catharanthus roseus and the evaluation of the factors which enhance the vincristine production. Background: An endophytic fungus Botryosphaeria laricina (CRS1) isolated from Catharanthus roseus demonstrated vinca alkaloid production under certain conditions. Objective: To Understand the conditions under which the fungus was able to produce vincristine and Read More

Background: One of the four most incident plant species in mangrove is the Laguncularia racemosa, widely used in popular medicine against inflammation and fever. Objective: Here, L. racemosa was investigated in relation to their phytochemical profile, antioxidant activity, cytotoxicity, antimicrobial and immunostimulatory effect. Methods: Aqueous extract was obtained from leaves of plant, its phytochemical profile was Read More

Background: Sarasvata churna is an Ayurvedic formulation for treatment and management of epilepsy and other maniac disorders since thousands of years. Objective: This study aimed to evaluate the in vitro antioxidant potential, total phenolics and flavonoids content, acute-oral-toxicity and anticonvulsant activity of Sarasvata churna. Materials & Methods: In vitro antioxidant activity of methanolic extract of Sarasvata churna Read More