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Volume 4, Issue 1
  • ISSN: 0250-6882
  • E-ISSN: 0250-6882
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Abstract

Background

Presepsin is a soluble analog of CD14, recently validated as a new biomarker for sepsis. Different cut-off levels of Presepsin for the diagnosis of sepsis have been proposed however, the optimum threshold for early clinical discrimination of sepsis from non-infectious conditions remains unknown.

Objective

This work was undertaken to define the reference interval of Presepsin for Sepsis according to the CLSI C28-A3c approved guideline.

Methods

Reference individuals (N=72) receiving in-patient care at ICU for sepsis and complications were selected for the study. Presepsin concentrations were measured by enzyme-linked immunosorbent assay. Reference limits were calculated using the non-parametric robust method.

Results

Overall, the reference range for Presepsin in sepsis patients was 24.2 -872.2 pg/mL (90% confidence interval). Peak values for males were relatively higher than for females and the presepsin concentrations were influenced by age.

Conclusion

Proposed reference interval could assist in accurate and early diagnosis of sepsis which would eventually improve the outcome in patients of all age groups.

© 2023 Bentham Science Publishers
© 2023 The Author(s). Published by Bentham Science Publisher. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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/content/journals/nemj/10.2174/04666230203113102
2023-04-14
2025-01-19

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/content/journals/nemj/10.2174/04666230203113102
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Standardized Criterion of Presepsin Reference Interval for Accurate and Early Diagnosis of Sepsis
NEW Emirates Medical J 4, e030223213419 (2023); https://doi.org/10.2174/04666230203113102
/content/journals/nemj/10.2174/04666230203113102
/content/journals/nemj/10.2174/04666230203113102
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  • Article Type:     Research Article
Keyword(s): CD14 antigen; Clinical and laboratory standard institute; Immunosorbent; Presepsin; Reference values; Sepsis

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