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Volume 5, Issue 1
  • ISSN: 0250-6882
  • E-ISSN: 0250-6882
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Abstract

Background

Vancomycin, used to treat severe gram-positive infections, can induce acute kidney injury. Some evidence introduced Interleukin-18 (IL-18) as an inflammatory mediator of ischemic damage to many organs and urinary IL-18 as a diagnostic biomarker of acute tubular necrosis.

Objective

The current study aimed to evaluate the urinary level of IL-18 after vancomycin therapy.

Methods

This cross-sectional study was conducted on patients under treatment with vancomycin selected from those referred to Dr. Sheikh Hospital, Mashhad, Iran, from 2018-2019. Urinary IL-18 was measured based on nanograms per milliliter using a human IL-18 enzyme-linked immunosorbent assay kit about this cytokine before vancomycin administration and then two days later. All the analyses were performed in SPSS software (version 25), and a P-value less than 0.05 was considered statistically significant.

Results

A total of 36 patients with a mean age of 40.06±36.67 months were included in the study. The mean scores of IL-18 before and after taking vancomycin were 1453.00±555.01 and 1713.00±660.98, respectively. The IL-18 was significantly lower before vancomycin consumption than the level reported after 48 h (P<0.05).

Conclusions

The present study highlighted a higher level of urinary IL-18 after vancomycin treatment, which may indicate kidney injuries. Therefore, it may be considered a potential biomarker of acute tubular necrosis in patients under vancomycin therapy.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2024-03-08
2025-01-31

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/content/journals/nemj/10.2174/0102506882278713240303174153
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Evaluation of Urinary Interleukin-18 Changes in Patients Treated with Vancomycin
NEW Emirates Medical J 5, e02506882278713 (2024); https://doi.org/10.2174/0102506882278713240303174153
/content/journals/nemj/10.2174/0102506882278713240303174153
/content/journals/nemj/10.2174/0102506882278713240303174153
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  • Article Type:     Research Article
Keyword(s): Acute kidney injury; Acute tubular necrosis; Kidney interleukin-18; Urinary; Vancomycin

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