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2000
Volume 5, Issue 1
  • ISSN: 0250-6882
  • E-ISSN: 0250-6882
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Abstract

Background

Despite the available clinical practice guidelines, many management decisions in bronchiolitis are made subjectively, resulting in variable length of stay and unplanned ICU admissions. We hypothesized that certain independent predictors would affect the length of stay (LOS) and care escalation.

Objectives

To identify predictors for increased LOS and ICU admissions in acute bronchiolitis.

Methods

We conducted a retrospective descriptive cohort study involving 589 children admitted to MZH with acute bronchiolitis in 2 years. Predictors evaluated were age, gender, family history of asthma, prematurity, fever, hypoxemia, comorbidities, RSV, and medications (salbutamol, steroids, and antibiotics).

Results

Acute bronchiolitis comprised 18.61% of Pediatric admissions and 6.2% of total hospital admissions. The mean age is 8.28±6.1(2-36 months); 83% were infants, 39.2% were girls, 15% were preterm, and 25.1% had a family history of asthma. Despite 84.2% having X-rays, significant findings were present in 21.3%. RSV positive 26.3%. The mean LOS was 3.6±1.6 (2-11 days).

Age less than 2 months(P=0.029 OR=1.8, CI1.1 - 3.3), family history of asthma (P=0.03 OR=1.8, CI1.14 - 2.9), hypoxemia on admission (P<0.001 OR=3, CI1.8 - 4.9), presence of comorbidity (P=0.012), and significant radiographic findings (P<0.002, OR=2.7, CI1.6 - 4.6) were predictors of longer LOS. Prematurity (P<0.001, OR 8.8, CI 2.7-28.4), RSV bronchiolitis (P<0.002, OR=3.02, CI=1.5 – 6.03), and hypoxemia on admission (P< 0.042 OR=4.6, CI1.1 - 14.9) qualified as independent predictors for escalated care.

Conclusion(s)

RSV bronchiolitis, especially in preterm infants, may prompt a low threshold for admission and escalating the care. Evidence-based treatments, early respiratory support, and treatment of comorbidities help to achieve the optimal LOS.

This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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References

  1. ShayD.K. HolmanR.C. NewmanR.D. LiuL.L. StoutJ.W. AndersonL.J. Bronchiolitis-associated hospitalizations among US children, 1980-1996.JAMA1999282151440144610.1001/jama.282.15.144010535434
    [Google Scholar]
  2. WeiglJ.A. PuppeW. SchmittH.J. Variables explaining the duration of hospitalization in children under two years of age admitted with acute airway infections: does respiratory syncytial virus have a direct impact?Klin. Padiatr.2004216171510.1055/s‑2004‑81768814747964
    [Google Scholar]
  3. WainwrightC. Acute viral bronchiolitis in children- a very common condition with few therapeutic options.Paediatr. Respir. Rev.2010111394510.1016/j.prrv.2009.10.00120113991
    [Google Scholar]
  4. DalzielS.R. HaskellL. O’BrienS. BorlandM.L. PlintA.C. BablF.E. OakleyE. Bronchiolitis.Lancet20224001034939240610.1016/S0140‑6736(22)01016‑935785792
    [Google Scholar]
  5. BordleyW.C. ViswanathanM. KingV.J. SuttonS.F. JackmanA.M. SterlingL. LohrK.N. Diagnosis and testing in bronchiolitis: a systematic review.Arch. Pediatr. Adolesc. Med.2004158211912610.1001/archpedi.158.2.11914757603
    [Google Scholar]
  6. ChamberlainJ.M. PatelK.M. PollackM.M. Association of emergency department care factors with admission and discharge decisions for pediatric patients.J. Pediatr.20061495644649.e310.1016/j.jpeds.2006.05.04717095336
    [Google Scholar]
  7. JohnsonD.W. AdairC. BrantR. HolmwoodJ. MitchellI. Differences in admission rates of children with bronchiolitis by pediatric and general emergency departments.Pediatrics20021104e4910.1542/peds.110.4.e4912359822
    [Google Scholar]
  8. GreenC.A. YeatesD. GoldacreA. SandeC. ParslowR.C. McShaneP. PollardA.J. GoldacreM.J. Admission to hospital for bronchiolitis in England: trends over five decades, geographical variation and association with perinatal characteristics and subsequent asthma.Arch. Dis. Child.2016101214014610.1136/archdischild‑2015‑30872326342094
    [Google Scholar]
  9. TumbaK. ComaruT. MachadoC. RibeiroM. PintoL.A. temporal trend of hospitalizations for acute bronchiolitis in infants under one year of age in brazil between 2008 and 2015.Rev. Paul. Pediatr.202038e201812010.1590/1984‑0462/2020/38/201812031778406
    [Google Scholar]
  10. Mendes-da-SilvaA. Gonçalves-PinhoM. FreitasA. AzevedoI. Trends in hospitalization for acute bronchiolitis in Portugal: 2000–2015.Pulmonology201925315416110.1016/j.pulmoe.2018.05.00229898876
    [Google Scholar]
  11. BrandP.L.P. Vaessen-VerberneA.A.P.H. Dutch Paediatric Respiratory Society Differences in management of bronchiolitis between hospitals in The Netherlands.Eur. J. Pediatr.2000159534334710.1007/s00431005128410834519
    [Google Scholar]
  12. WillsonD.F. HornS.D. HendleyJ.O. SmoutR. GassawayJ. Effect of practice variation on resource utilization in infants hospitalized for viral lower respiratory illness.Pediatrics2001108485185510.1542/peds.108.4.85111581435
    [Google Scholar]
  13. WennbergJ.E. Unwarranted variations in healthcare delivery: implications for academic medical centres.BMJ2002325737096196410.1136/bmj.325.7370.96112399352
    [Google Scholar]
  14. SchuhS. BablF.E. DalzielS.R. FreedmanS.B. MaciasC.G. StephensD. SteeleD.W. FernandesR.M. ZemekR. PlintA.C. FlorinT.A. LyttleM.D. JohnsonD.W. GouinS. SchnadowerD. KlassenT.P. BajajL. BenitoJ. KharbandaA. KuppermannN. Pediatric Emergency Research Networks (PERN) Practice variation in acute bronchiolitis: A pediatric emergency research networks study.Pediatrics20171406e2017084210.1542/peds.2017‑084229184035
    [Google Scholar]
  15. WattR. JacksonG. TurnerS. G162(P) what predicts duration of hospital stay for bronchiolitis?Arch. Dis. Child.201398S1Suppl. 1A7510.1136/archdischild‑2013‑304107.174
    [Google Scholar]
  16. Rodríguez-MartínezC.E. Sossa-BriceñoM.P. NinoG. Predictors of prolonged length of hospital stay for infants with bronchiolitis.J. Investig. Med.201866698699110.1136/jim‑2018‑00070829588331
    [Google Scholar]
  17. SchuhS. KwongJ.C. HolderL. GravesE. MacdonaldE.M. FinkelsteinY. Predictors of critical care and mortality in bronchiolitis after emergency department discharge.J. Pediatr.2018199217222.e110.1016/j.jpeds.2018.04.01029747934
    [Google Scholar]
  18. FreireG. KuppermannN. ZemekR. PlintA.C. BablF.E. DalzielS.R. FreedmanS.B. AtenafuE.G. StephensD. SteeleD.W. FernandesR.M. FlorinT.A. KharbandaA. LyttleM.D. JohnsonD.W. SchnadowerD. MaciasC.G. BenitoJ. SchuhS. Pediatric Emergency Research Networks (PERN) Predicting escalated care in infants with bronchiolitis.Pediatrics20181423e2017425310.1542/peds.2017‑425330126934
    [Google Scholar]
  19. SaeedB. SharifH. Al-ShahrabiR. AdreesA. AlkokhardiZ. Incidence and seasonal variation of hospital admissions for acute bronchiolitis among children younger than two years in a Northern Emirates hospital.Advances in Biomedical and Health Sciences20221313113610.4103/abhs.abhs_16_22
    [Google Scholar]
  20. HasegawaK. JarttiT. MansbachJ.M. LahamF.R. JewellA.M. EspinolaJ.A. PiedraP.A. CamargoC.A.Jr Respiratory syncytial virus genomic load and disease severity among children hospitalized with bronchiolitis: multicenter cohort studies in the United States and Finland.J. Infect. Dis.2015211101550155910.1093/infdis/jiu65825425699
    [Google Scholar]
  21. HowidiM. RajahJ. AbushrarZ. ParsonsH. The severity of respiratory syncytial virus bronchiolitis in young infants in the United Arab Emirates.J. Trop. Pediatr.2006531222610.1093/tropej/fml04517008442
    [Google Scholar]
  22. Al ShibliA. NouredinM.B. Al AmriA. IramD. NarchiH. Epidemiology of bronchiolitis in hospitalized infants at Tawam Hospital, Al Ain, United Arab Emirates.Open Respir. Med. J.20211571310.2174/187430640211501000734249176
    [Google Scholar]
  23. JepsenM.T. TrebbienR. EmborgH.D. KrauseT.G. SchønningK. VoldstedlundM. NielsenJ. FischerT.K. Incidence and seasonality of respiratory syncytial virus hospitalisations in young children in Denmark, 2010 to 2015.Euro Surveill.2018233170016310.2807/1560‑7917.ES.2018.23.3.17‑0016329386093
    [Google Scholar]
  24. MeissnerH.C. Uncertainty in the management of viral lower respiratory tract disease.Pediatrics200110841000100310.1542/peds.108.4.100011581456
    [Google Scholar]
  25. WangE.E.L. LawB.J. BoucherF.D. StephensD. RobinsonJ.L. DobsonS. LangleyJ.M. McDonaldJ. MacDonaldN.E. MitchellI. Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study of admission and management variation in patients hospitalized with respiratory syncytial viral lower respiratory tract infection.J. Pediatr.1996129339039510.1016/S0022‑3476(96)70071‑98804328
    [Google Scholar]
  26. Rivera-SepulvedaA. Garcia-RiveraE.J. Epidemiology of bronchiolitis: a description of emergency department visits and hospitalizations in Puerto Rico, 2010–2014.Trop. Med. Health20174512410.1186/s41182‑017‑0064‑729021713
    [Google Scholar]
  27. RalstonS.L. LieberthalA.S. MeissnerH.C. AlversonB.K. BaleyJ.E. GadomskiA.M. JohnsonD.W. LightM.J. MaraqaN.F. MendoncaE.A. PhelanK.J. ZorcJ.J. Stanko-LoppD. BrownM.A. NathansonI. RosenblumE. SaylesS.III Hernandez-CancioS. RalstonS.L. LieberthalA.S. MeissnerH.C. AlversonB.K. BaleyJ.E. GadomskiA.M. JohnsonD.W. LightM.J. MaraqaN.F. MendoncaE.A. PhelanK.J. ZorcJ.J. Stanko-LoppD. BrownM.A. NathansonI. RosenblumE. SaylesS.III Hernandez-CancioS. American Academy of Pediatrics Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis.Pediatrics20141345e1474e150210.1542/peds.2014‑274225349312
    [Google Scholar]
  28. Quintos-AlaghebandM.L. NoyolaE. MakvanaS. El-ChaarG. WangS. CalixteR. KrilovL.R. Reducing antibiotic use in respiratory syncytial virus—a quality improvement approach to antimicrobial stewardship.Pediatr. Qual. Saf.201726e04610.1097/pq9.000000000000004630229182
    [Google Scholar]
  29. MansbachJ.M. McAdamA.J. ClarkS. HainP.D. FloodR.G. AcholonuU. CamargoC.A.Jr Prospective multicenter study of the viral etiology of bronchiolitis in the emergency department.Acad. Emerg. Med.200815211111810.1111/j.1553‑2712.2007.00034.x18275439
    [Google Scholar]
  30. PiedraP.A. PiedraP.A. TeachS.J. SullivanA.F. ForgeyT. ClarkS. EspinolaJ.A. CamargoC.A.Jr MARC-30 Investigators Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis.Arch. Pediatr. Adolesc. Med.2012166870070610.1001/archpediatrics.2011.166922473882
    [Google Scholar]
  31. KimG.R. NaM.S. BaekK.S. LeeS.J. LeeK.S. JungY.H. JeeH.M. KwonT.H. HanM.Y. SheenY.H. Clinical predictors of chest radiographic abnormalities in young children hospitalized with bronchiolitis: a single center study.Korean J. Pediatr.2016591247147610.3345/kjp.2016.59.12.47128194212
    [Google Scholar]
  32. American Academy of Pediatrics. Respiratory syncytial virus.Red Book: 2015 Report of the Committee on Infectious Diseases. Kimberlin DW, Brady MT, Jackson MA, Long SS, Eds. Elk Grove Village, IL: American Academy of Pediatrics201566776
  33. ParkerM.J. AllenU. StephensD. LalaniA. SchuhS. Predictors of major intervention in infants with bronchiolitis.Pediatr. Pulmonol.200944435836310.1002/ppul.2101019283838
    [Google Scholar]
  34. DasS. DunbarS. TangY.W. Laboratory diagnosis of respiratory tract infections in children – the State of the Art.Front. Microbiol.20189247810.3389/fmicb.2018.0247830405553
    [Google Scholar]
  35. Abdel-KaderA. NassarM.F. QabazardZ. DisawiM. Imaging in acute bronchiolitis: Evaluation of the current practice in a Kuwaiti governmental hospital and its possible impact on hospitalization period.Open Respir. Med. J.2018121758010.2174/187430640181201007530988829
    [Google Scholar]
  36. ChristakisD.A. CowanC.A. GarrisonM.M. MolteniR. MarcuseE. ZerrD.M. Variation in inpatient diagnostic testing and management of bronchiolitis.Pediatrics2005115487888410.1542/peds.2004‑129915805359
    [Google Scholar]
  37. SchuhS. LalaniA. AllenU. MansonD. BabynP. StephensD. MacPheeS. MokanskiM. KhaikinS. DickP. Evaluation of the utility of radiography in acute bronchiolitis.J. Pediatr.2007150442943310.1016/j.jpeds.2007.01.00517382126
    [Google Scholar]
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  • Article Type:
    Research Article
Keyword(s): Acute bronchiolitis; Clinical; Hospital; Physicians; Respiratory tract; Serious infection
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