Mini-Reviews in Organic Chemistry - Volume 18, Issue 8, 2021

Cinnamic acid and cinnamaldehyde may be obtained from renewable plant bio-mass, Cinnamon plants; therefore these compounds should be considered as bio-based platform chemicals for the synthesis of novel substances. This review describes recent achievements in organic synthesis based on transformations of cinnamaldehyde, cinnamic acid and its derivatives, focusing, mainly, on the preparation of biologically activ Read More

Pyrimidobenzothiazoles and its derivatives are important structural scaffolds in the field of synthetic organic chemistry and medicinal chemistry. The review is focused on one pot multicomponent approaches for generating pyrimidobenzothiazoles and its derivatives along with their interesting biological profile over the last ten years. Several eco-benign and cost effective approaches such as nano catalyst, ionic liquid, metal, soli Read More

Covalent Organic Frameworks (COFs) are covalently bonded polymers that are synthesised applying a bottom-up approach using molecular building units that have pre-designed geometry. COFs are crystalline and have control over the position of building units in two and three dimensions, due to which highly regular, rigid, and porous structures can be developed for tuning chemical and physical properties of the network. The pres Read More

A classic reductive amidation/amination (C-N bond formation) approach for DNJ synthesis has been widely practiced due to the availability of low-cost reagents. The key steps for this synthetic route are Swern oxidation, reductive amidation/amination, and debenzylation. A lot of attention has been given to the optimization of these key intermediates apart from debenzylation. This review aims to describe the deprotection adva Read More

Food safety arising from exogenous contaminants has become a global concern. The development of simple, rapid and sensitive methods for effective detection and management of trace levels of exogenous contaminants has emerged as a hotspot, as well as the important priorities in food industry. Nanozymes that are defined as the emerging enzyme-like nanomaterials with robust catalytic activity, simple preparation, Read More

Benzimidazole and its derivatives are privileged heterocyclic motifs and important building blocks for the development of the biologically active compound. However, several research reports are produced in a short period of time due to the rapid production of new drugs having a benzimidazole nucleus. In order to understand the current status of the benzimidazole nucleus in medicinal chemistry, it is therefore im Read More

Heterocyclic compounds are important because they have almost all types of pharmacological properties. Due to these properties of heterocyclic compounds, they attracted the researchers for the development of more effective newer drug molecules. In this review, we are focused on benzothiazole and its derivatives, which are used for the synthesis of various biologically active molecules. Benzothiazole derivatives hav Read More

Schiff base or imine or azomethine is one of the most important organic compounds that has been reported to play a significant role in various biological processes. The group is a part of natural or non-natural compounds and is involved as important precursors, as diversified agents and as intermediates, in the synthesis of biologically active agents. The review outlines the detailed design strategy, synthesis and structure-act Read More

Triazines and their oxo derivatives are a representative class of heterocyclic compounds which have attracted great attention in organic synthesis and medicinal chemistry as they have been associated with a broad range of pharmacological activities. 1,2,4-Triazines and their oxo derivatives exhibit a broad range of biological activities, including antimicrobial, antifungal, anticancer, antiinflammatory, besides having importanc Read More

This review deals with the synthetic methods, chemical reactions, and applications of triazolopyrimidine derivatives. The synthetic methods and chemical reactions are subdivided into groups according to the junction between triazole and pyrimidine moieties for instance [1,2,4]triazolo[1,5- a]pyrimidine, [1,2,4]triazolo[1,5-c]pyrimidine, [1,2,3]triazolo[1,5-a]pyrimidine, [1,2,3]triazolo[1,5- c]pyrimidine, [1,2,4]triazolo[4,3-c]pyri Read More