Mini-Reviews in Organic Chemistry - Volume 18, Issue 2, 2021

The chemistry of hypervalent iodine reagents has emerged as an astonishing field in synthetic organic chemistry owing to its easy availability and benign environmental features. Hypervalent iodine reagents are mostly employed as alternatives in various metal-catalyzed reactions since they show similar reactivity to the transition metals, are less toxic, and less expensive. These reagents are often used as oxidants as well as e Read More

Iodine(III)-based reagents have been broadly used in oxidative reactions for structural functionalization with several functional groups. Among the more relevant and useful synthetic transformations using these hypervalent λ3-reagents, the fluorination, chlorination, bromination, as well as the iodination protocols, can be found. Herein, we present some of the most representative oxidative halogenation procedures of arenes, ol Read More

[18F]-labeled drugs and radioligands are most frequently used in positron-emission tomography (PET) radiopharmaceuticals for both clinical and preclinical research. Various methods for the introduction of [18F]fluorine into complex molecules through fluorination reactions have been reported. Herein, recent advances in [18F]-fluorination utilizing aryliodonium(III) compounds are highlighted.

The importance of selenium in biology, in organic catalysis, and green chemistry is well established. Selenoproteins, among which are ubiquitous Glutathione Peroxidases (GPx), play a key role in mitigating oxidative stress by reducing H2O2 and hydroperoxides using glutathione as a cofactor. Organoselenides, particularly diphenyl diselenide, in the presence of H2O2, are efficient and often green oxygen transfer agents in impo Read More

The arylaluminum reagents are good nucleophiles for organic reactions because of their high reactivity, high chemoselective, low toxicity, and ease of preparation. Therefore, arylaluminum reagents are widely applied in many organic reactions. This review summarizes the recent advancement of the arylaluminum reagents applied in cross-coupling reactions, involving various reaction systems and properties of reaction.

This review reports various synthetic routes of pyrazolone/ pyrazolinone derivatives via the addition of cycloaddition, condensation, cyclocondensation, modification, alkylation, as well as formylation, regioselective, and ring-opening reactions under reflux, microwave irradiation, and/ or ultrasonication conditions. It also presents critical chemical behaviors towards nucleophilic and electrophilic reagents. The chemi Read More

Several easy, efficient and convenient procedures to access indoles fused heterocyclic systems are described in this review. These heterocyclic systems were synthesized from several cyclic or acyclic molecules via a variety of reactions such as Diels-Alder reaction, Michael addition, Morita- Baylis-Hillmann reaction and many other domino/Cascade approaches with high selectivity. Most of the given protocols in this review pro Read More

The removal of volatile compounds with unfavorable fishy odor from fish has attracted considerable research attention especially in surimi production industry. The binding of these volatile compounds by fish proteins are reported to affect the deodorization of fishy odor. To remove the protein- bound fishy substances effectively, the mechanisms underlying the interaction between proteins and flavor substances and met Read More